Thyroid-like follicular carcinoma of the kidney

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Thyroid-like follicular carcinoma of the kidney, also thyroid-like follicular renal cell carcinoma (abbreviated TLF-RCC or TLFRCC), is a recently described rare kidney tumour.

It is considered an emerging entity by the Vancouver modification of the 2004 WHO classification of renal neoplasia.[1]

General

  • Extremely rare - less than 15 cases reported in the literature.[1]
  • Large age range (29-83 years old).

Gross

  • Solid, brown and well circumscribed.

Microscopic

Features:[1]

  • Thyroid follicule-like structures - both macrofollicular and/or microfollicular.
    • Contain dense-appearing eosinophilic material.
  • Encapuslated.
  • Nuclei round and regular with prominent nucleoli (ISUP nucleolar grade 2 or 3).

DDx:

Images

IHC

Features:[1]

  • TTF-1 -ve.
  • Thyroglobulin -ve.
  • CK7 +ve/-ve.
  • PAX8 +ve/-ve.

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 Srigley, JR.; Delahunt, B.; Eble, JN.; Egevad, L.; Epstein, JI.; Grignon, D.; Hes, O.; Moch, H. et al. (Oct 2013). "The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia.". Am J Surg Pathol 37 (10): 1469-89. doi:10.1097/PAS.0b013e318299f2d1. PMID 24025519.
  2. ↑ Ghaouti, M.; Roquet, L.; Baron, M.; Pfister, C.; Sabourin, JC. (2014). "Thyroid-like follicular carcinoma of the kidney: a case report and review of the literature.". Diagn Pathol 9 (1): 186. doi:10.1186/s13000-014-0186-8. PMID 25293503.
  3. ↑ Wu, WW.; Chu, JT.; Nael, A.; Rezk, SA.; Romansky, SG.; Shane, L. (2014). "Thyroid-like follicular carcinoma of the kidney in a young patient with history of pediatric acute lymphoblastic leukemia.". Case Rep Pathol 2014: 313974. doi:10.1155/2014/313974. PMID 25133003.
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