Hereditary diffuse gastric cancer

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Signet ring cell carcinoma, as may be seen in hereditary diffuse gastric cancer. H&E stain.

Hereditary diffuse gastric cancer, abbreviated HDGC, is an important hereditary cause of diffuse gastric cancer.[1]

It is caused by mutations in the epithelial cadherin gene (also E-cadherin and CDH1).[2][3]


It is associated with:

See also


  1. Sereno M, Aguayo C, Guillén Ponce C, et al. (September 2011). "Gastric tumours in hereditary cancer syndromes: clinical features, molecular biology and strategies for prevention". Clin Transl Oncol 13 (9): 599–610. PMID 21865131.
  2. Online 'Mendelian Inheritance in Man' (OMIM) 137215
  3. Online 'Mendelian Inheritance in Man' (OMIM) 192090