Mucinous fibroplasia

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Micrograph showing mucinous fibroplasia. H&E stain. (WC)

Mucinous fibroplasia, also collagenous micronodules, is a finding seen in the prostate gland that is considered pathognomonic for prostate carcinoma by many genitourinary pathologists.[1][2]


  • Considered pathognomonic by 64% of genitourinary pathologists in one survey with 64 respondents.[1]
  • Thought to arise from intraglandular mucin.[citation needed]



  • Small collegneous-like nodules within (malignant) prostatic glands.


See also


  1. 1.0 1.1 Egevad, L.; Allsbrook, WC.; Epstein, JI. (Mar 2006). "Current practice of diagnosis and reporting of prostate cancer on needle biopsy among genitourinary pathologists.". Hum Pathol 37 (3): 292-7. PMID 16613324.
  2. Baisden, BL.; Kahane, H.; Epstein, JI. (Aug 1999). "Perineural invasion, mucinous fibroplasia, and glomerulations: diagnostic features of limited cancer on prostate needle biopsy.". Am J Surg Pathol 23 (8): 918-24. PMID 10435561.