Central neurocytoma

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Central neurocytoma, abbreviated CNC, is a rare neuropathology tumour.

General

  • Rare - less than 1% of brain tumours.[1]
  • Benign.
  • First described in 1982.[1]

Gross/radiology

  • Intraventricular.[2]
    • Characteristically attached to the septum pellucidum.[3]

Microscopic

Features:[4]

  • Perivascular pseudorosette = circular/flower-like arrangement of cells with blood vessel at the centre.[5]
  • Islands of neuropil.
  • Polygonal cells with a perinuclear halo.

DDx:

DDx of perivascular pseudorosette:

Images

www:

IHC

  • MIB1 - high may predict re-occurance.[6]

See also

References

  1. 1.0 1.1 Chuang, MT.; Lin, WC.; Tsai, HY.; Liu, GC.; Hu, SW.; Chiang, IC.. "3-T proton magnetic resonance spectroscopy of central neurocytoma: 3 case reports and review of the literature.". J Comput Assist Tomogr 29 (5): 683-8. PMID 16163043.
  2. URL: http://moon.ouhsc.edu/kfung/jty1/Com/Com307-1-Diss.htm. Accessed on: 12 January 2012.
  3. Kerkeni, A.; Ben Lakhdher, Z.; Rkhami, M.; Sebai, R.; Belguith, L.; Khaldi, M.; Ben Hamouda, M. (Oct 2010). "[Central neurocytoma: Study of 32 cases and review of the literature].". Neurochirurgie 56 (5): 408-14. doi:10.1016/j.neuchi.2010.07.001. PMID 20692674.
  4. URL: http://moon.ouhsc.edu/kfung/jty1/Com/Com307-1-Diss.htm. Accessed on: 27 May 2011.
  5. Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  6. Schmidt, MH.; Gottfried, ON.; von Koch, CS.; Chang, SM.; McDermott, MW. (Feb 2004). "Central neurocytoma: a review.". J Neurooncol 66 (3): 377-84. PMID 15015671.