Difference between revisions of "Zenker's diverticulum"

Jump to navigation Jump to search

Zenker's diverticulum (view source)

Revision as of 15:25, 21 January 2016

2,617 bytes added ,  15:25, 21 January 2016
+infobox
(+infobox)
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Pharyngoesophageal diverticulum -- low mag.jpg
| Width      =
| Caption    = Consistent with Zenker's diverticulum (squamous mucosa). [[H&E stain]].
| Synonyms  = cricopharyngeal diverticulum, pharyngoesophageal diverticulum and hypopharyngeal diverticulum
| Micro      = squamous mucosa without [[nuclear atypia]] +/- parakeratosis
| Subtypes  =
| LMDDx      = [[squamous dysplasia of the esophagus]], [[squamous cell carcinoma of the esophagus]], [[squamous cell carcinoma of the head and neck]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[esophagus]]/pharynx
| Assdx      =
| Syndromes  =
| Clinicalhx = elderly
| Signs      =
| Symptoms  = dysphagia
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
| Tx        = excision
}}
'''Zenker's diverticulum''' is an outpouching of the mucosa and submucosa at the junction of the pharynx and [[esophagus]].
'''Zenker's diverticulum''' is an outpouching of the mucosa and submucosa at the junction of the pharynx and [[esophagus]].


Line 6: Line 38:
*[[Clinical diagnosis]].
*[[Clinical diagnosis]].
*Benign.
*Benign.
**[[Squamous cell carcinoma]] may arise from it.<ref name=pmid26415863>{{Cite journal  | last1 = Acar | first1 = T. | last2 = Savaş | first2 = R. | last3 = Kocaçelebi | first3 = K. | last4 = Ersöz | first4 = G. | title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. | journal = Dis Esophagus | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1111/dote.12406 | PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal  | last1 = Wakita | first1 = A. | last2 = Motoyama | first2 = S. | last3 = Sato | first3 = Y. | last4 = Yoshino | first4 = K. | last5 = Sasaki | first5 = T. | last6 = Saito | first6 = H. | last7 = Minamiya | first7 = Y. | last8 = Ogawa | first8 = J. | title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. | journal = Int J Surg Case Rep | volume = 3 | issue = 11 | pages = 574-6 | month =  | year = 2012 | doi = 10.1016/j.ijscr.2012.07.010 | PMID = 22940699 }}</ref>
**A malignancy ([[squamous cell carcinoma]]) may arise from it;<ref name=pmid26415863>{{Cite journal  | last1 = Acar | first1 = T. | last2 = Savaş | first2 = R. | last3 = Kocaçelebi | first3 = K. | last4 = Ersöz | first4 = G. | title = Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG-PET/CT to the diagnosis. | journal = Dis Esophagus | volume =  | issue =  | pages =  | month = Sep | year = 2015 | doi = 10.1111/dote.12406 | PMID = 26415863 }}</ref><ref name=pmid22940699>{{Cite journal  | last1 = Wakita | first1 = A. | last2 = Motoyama | first2 = S. | last3 = Sato | first3 = Y. | last4 = Yoshino | first4 = K. | last5 = Sasaki | first5 = T. | last6 = Saito | first6 = H. | last7 = Minamiya | first7 = Y. | last8 = Ogawa | first8 = J. | title = Squamous cell carcinoma in an esophageal diverticulum below the aortic arch. | journal = Int J Surg Case Rep | volume = 3 | issue = 11 | pages = 574-6 | month =  | year = 2012 | doi = 10.1016/j.ijscr.2012.07.010 | PMID = 22940699 }}</ref> seen in ~0.3% of cases.<ref>{{Ref GLP|7}}</ref>
*Uncommon.<ref name=pmid24055983/>
*Relatively uncommon<ref name=pmid24055983/> - but most common among esophageal diverticula.<ref>{{Ref GLP|6}}</ref>


Clinical:<ref name=pmid24055983>{{Cite journal  | last1 = Law | first1 = R. | last2 = Katzka | first2 = DA. | last3 = Baron | first3 = TH. | title = Zenker's Diverticulum. | journal = Clin Gastroenterol Hepatol | volume = 12 | issue = 11 | pages = 1773-82; quiz e111-2 | month = Nov | year = 2014 | doi = 10.1016/j.cgh.2013.09.016 | PMID = 24055983 }}</ref>
Clinical:<ref name=pmid24055983>{{Cite journal  | last1 = Law | first1 = R. | last2 = Katzka | first2 = DA. | last3 = Baron | first3 = TH. | title = Zenker's Diverticulum. | journal = Clin Gastroenterol Hepatol | volume = 12 | issue = 11 | pages = 1773-82; quiz e111-2 | month = Nov | year = 2014 | doi = 10.1016/j.cgh.2013.09.016 | PMID = 24055983 }}</ref>
*Eldery.
*Eldery.
*Dysphagia.
*Dysphagia - difficultly swallowing.
*May mimic a [[thyroid gland|thyroid]] nodule.<ref name=pmid20665743>{{Cite journal  | last1 = Singaporewalla | first1 = RM. | last2 = Mukherjee | first2 = JJ. | last3 = Thamboo | first3 = TP. | last4 = Cheah | first4 = WK. | title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. | journal = Head Neck | volume = 33 | issue = 12 | pages = 1800-3 | month = Dec | year = 2011 | doi = 10.1002/hed.21474 | PMID = 20665743 }}</ref>
*May mimic a [[thyroid gland|thyroid]] nodule.<ref name=pmid20665743>{{Cite journal  | last1 = Singaporewalla | first1 = RM. | last2 = Mukherjee | first2 = JJ. | last3 = Thamboo | first3 = TP. | last4 = Cheah | first4 = WK. | title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. | journal = Head Neck | volume = 33 | issue = 12 | pages = 1800-3 | month = Dec | year = 2011 | doi = 10.1002/hed.21474 | PMID = 20665743 }}</ref>
*+/-Aspiration of food.
*+/-Aspiration of food.
Line 22: Line 54:
</gallery>
</gallery>
==Microscopic==
==Microscopic==
Features:
Features:<ref name=pmid20665743>{{Cite journal  | last1 = Singaporewalla | first1 = RM. | last2 = Mukherjee | first2 = JJ. | last3 = Thamboo | first3 = TP. | last4 = Cheah | first4 = WK. | title = Pharyngoesophageal diverticulum resembling a thyroid nodule on ultrasound. | journal = Head Neck | volume = 33 | issue = 12 | pages = 1800-3 | month = Dec | year = 2011 | doi = 10.1002/hed.21474 | PMID = 20665743 }}</ref>
*Squamous mucosa.
*Squamous mucosa without [[nuclear atypia]] +/- parakeratosis.
 
DDx:
*[[Squamous dysplasia of the esophagus]].
*[[Squamous cell carcinoma of the esophagus]].
*[[Squamous cell carcinoma of the head and neck]].
 
===Images===
<gallery>
Image: Pharyngoesophageal diverticulum -- very low mag.jpg | ZD - very low mag. (WC)
Image: Pharyngoesophageal diverticulum - alt -- very low mag.jpg | ZD - very low mag. (WC)
Image: Pharyngoesophageal diverticulum -- low mag.jpg | ZD - low mag. (WC)
Image: Pharyngoesophageal diverticulum -- intermed mag.jpg | ZD - intermed. mag. (WC)
</gallery>
 
==Sign out==
<pre>
Submitted as "Zenker's Diverticulum", Excision:
- Squamous mucosa with parakeratosis, mild chronic inflammation
  and fibrosis; compatible with Zenker's diverticulum.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.
</pre>
 
===Alternate===
<pre>
Submitted as "Zenker's Diverticulum", Excision:
- Squamous mucosa with mild chronic inflammation and reactive
  changes; compatible with Zenker's diverticulum.
- Benign skeletal muscle.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.  
</pre>


==See also==
==See also==
Michael
48,454

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/40942...42281"

Navigation menu