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Difference between revisions of "Yolk sac tumour"
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| LMDDx = [[embryonal carcinoma]], [[mixed germ cell tumour]] | | LMDDx = [[embryonal carcinoma]], [[mixed germ cell tumour]] | ||
| Stains = | | Stains = | ||
| IHC = [[AFP]] +ve, [[glypican 3]] +ve, OCT3 -ve, [[CK19]] +ve | | IHC = [[AFP]] +ve, [[glypican 3]] +ve, OCT3 -ve, [[CK19]] +ve, AE1/AE3 +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 14: | Line 14: | ||
| Gross = white/yellow mucinous infiltrative mass | | Gross = white/yellow mucinous infiltrative mass | ||
| Grossing = [[orchiectomy grossing]] | | Grossing = [[orchiectomy grossing]] | ||
| Staging = [[testicular cancer staging]] | |||
| Site = [[testis]], other | | Site = [[testis]], other | ||
| Assdx = | | Assdx = | ||
| Line 81: | Line 82: | ||
DDx: | DDx: | ||
*[[Embryonal carcinoma]]. | *[[Embryonal carcinoma]] - more [[nuclear atypia]], nuclei usually overlap and classically vesicular. | ||
*[[Mixed germ cell tumour]]. | *[[Mixed germ cell tumour]]. | ||
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Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC) | Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC) | ||
Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC) | Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC) | ||
</gallery> | |||
====Case 3==== | |||
<gallery> | |||
Image: Yolk sac tumour -- low mag.jpg | YST - low mag. (WC) | |||
Image: Yolk sac tumour -- intermed mag.jpg | YST - intermed. mag. (WC) | |||
Image: Yolk sac tumour -- high mag.jpg | YST - high mag. (WC) | |||
Image: Yolk sac tumour -- very high mag.jpg | YST - very high mag. (WC) | |||
</gallery> | </gallery> | ||
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*[[Glypican 3]] +ve. | *[[Glypican 3]] +ve. | ||
**More sensitive than AFP.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | **More sensitive than AFP.<ref name=pmid20438407>{{Cite journal | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref> | ||
*CD117 +ve (~60% +ve in a series of 52 solid YSTs<ref>{{cite journal |authors=Kao CS, Idrees MT, Young RH, Ulbright TM |title=Solid pattern yolk sac tumor: a morphologic and immunohistochemical study of 52 cases |journal=Am J Surg Pathol |volume=36 |issue=3 |pages=360–7 |date=March 2012 |pmid=22261704 |doi=10.1097/PAS.0b013e31823c510b |url=}}</ref>). | |||
Others: | Others: | ||
| Line 122: | Line 132: | ||
*Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | *Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | ||
*[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | *[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | ||
*SOX2 -ve (0 of 17<ref name=pmid19369635>{{cite journal |authors=Nonaka D |title=Differential expression of SOX2 and SOX17 in testicular germ cell tumors |journal=Am J Clin Pathol |volume=131 |issue=5 |pages=731–6 |date=May 2009 |pmid=19369635 |doi=10.1309/AJCP7MNCNBCRN8NO |url=}}</ref>). | |||
*SOX17 +ve (17 of 17 cases<ref name=pmid19369635/>). | |||
A panel: | |||
*SALL4 +ve, AE1/AE3 +ve, CD30 -ve, glypican-3 +ve. | |||
==See also== | ==See also== | ||