48,453
edits
Difference between revisions of "Yolk sac tumour"
Jump to navigation
Jump to search
no edit summary
| (3 intermediate revisions by the same user not shown) | |||
| Line 13: | Line 13: | ||
| IF = | | IF = | ||
| Gross = white/yellow mucinous infiltrative mass | | Gross = white/yellow mucinous infiltrative mass | ||
| Grossing = [[ | | Grossing = [[orchiectomy grossing]] | ||
| Staging = [[ | | Staging = [[testicular cancer staging]] | ||
| Site = [[testis]], other | | Site = [[testis]], other | ||
| Assdx = | | Assdx = | ||
| Line 82: | Line 82: | ||
DDx: | DDx: | ||
*[[Embryonal carcinoma]]. | *[[Embryonal carcinoma]] - more [[nuclear atypia]], nuclei usually overlap and classically vesicular. | ||
*[[Mixed germ cell tumour]]. | *[[Mixed germ cell tumour]]. | ||
| Line 96: | Line 96: | ||
Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC) | Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC) | ||
Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC) | Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC) | ||
</gallery> | |||
====Case 3==== | |||
<gallery> | |||
Image: Yolk sac tumour -- low mag.jpg | YST - low mag. (WC) | |||
Image: Yolk sac tumour -- intermed mag.jpg | YST - intermed. mag. (WC) | |||
Image: Yolk sac tumour -- high mag.jpg | YST - high mag. (WC) | |||
Image: Yolk sac tumour -- very high mag.jpg | YST - very high mag. (WC) | |||
</gallery> | </gallery> | ||
| Line 123: | Line 131: | ||
*Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | *Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi = | PMID = 89123 }}</ref> | ||
*[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | *[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref> | ||
*SOX2 -ve (0 of 17<ref name=pmid19369635>{{cite journal |authors=Nonaka D |title=Differential expression of SOX2 and SOX17 in testicular germ cell tumors |journal=Am J Clin Pathol |volume=131 |issue=5 |pages=731–6 |date=May 2009 |pmid=19369635 |doi=10.1309/AJCP7MNCNBCRN8NO |url=}}</ref>). | |||
*SOX17 +ve (17 of 17 cases<ref name=pmid19369635/>). | |||
==See also== | ==See also== | ||