Difference between revisions of "Yolk sac tumour"

Jump to navigation Jump to search

Yolk sac tumour (view source)

Revision as of 13:51, 14 November 2023

2,277 bytes added ,  13:51, 14 November 2023
no edit summary
(17 intermediate revisions by the same user not shown)
Line 8: Line 8:
| LMDDx      = [[embryonal carcinoma]], [[mixed germ cell tumour]]
| LMDDx      = [[embryonal carcinoma]], [[mixed germ cell tumour]]
| Stains    =
| Stains    =
| IHC        = AFP +ve, glypican 3 +ve, OCT3 -ve
| IHC        = [[AFP]] +ve, [[glypican 3]] +ve, OCT3 -ve, [[CK19]] +ve
| EM        =
| EM        =
| Molecular  =
| Molecular  =
| IF        =
| IF        =
| Gross      = white/yellow mucinous infiltrative mass
| Gross      = white/yellow mucinous infiltrative mass
| Grossing  =
| Grossing  = [[orchiectomy grossing]]
| Staging    = [[testicular cancer staging]]
| Site      = [[testis]], other
| Site      = [[testis]], other
| Assdx      =
| Assdx      =
Line 55: Line 56:
*Architecure - variable.
*Architecure - variable.
*#Reticular - most common according to WMSP.<ref name=Ref_WMSP369>{{Ref WMSP|369}}</ref>
*#Reticular - most common according to WMSP.<ref name=Ref_WMSP369>{{Ref WMSP|369}}</ref>
*#Microcystic - most common according to ''webpathology.com''.<ref name=webpath_case34>URL: [http://webpathology.com/image.asp?case=34&n=1 http://webpathology.com/image.asp?case=34&n=1]. Accessed on: March 8, 2010.</ref> 
*#Microcystic.  
*#*Lace-like pattern.
*#*Lace-like pattern.
*#Endodermal sinus-like - has Schiller-Duval bodies.
*#Endodermal sinus-like - has Schiller-Duval bodies.
Line 69: Line 70:
Notes:
Notes:
*Has a loose stroma/vaguely discohesive -- unlike embryonal carcinoma.
*Has a loose stroma/vaguely discohesive -- unlike embryonal carcinoma.
*How to remember patterns ''REM PS GAPEH'' = reticular, endodermal sinus, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric, hepatoid.
*How to remember patterns ''REMember PlS GAP EH'' (or ''REM PS GAPEH'') = reticular, endodermal sinus, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric, hepatoid.
*Yolk sac tumours in adults are essentially always a component of a [[mixed germ cell tumour]], i.e. if one sees a pure yolk sac tumour in an adult, it is probably under sampled.<ref name=pmid1203848>{{Cite journal  | last1 = Talerman | first1 = A. | title = The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. | journal = Cancer | volume = 36 | issue = 1 | pages = 211-5 | month = Jul | year = 1975 | doi =  | PMID = 1203848 }}</ref>
*Yolk sac tumours in adults are essentially always a component of a [[mixed germ cell tumour]], i.e. if one sees a pure yolk sac tumour in an adult, it is probably under sampled.<ref name=pmid1203848>{{Cite journal  | last1 = Talerman | first1 = A. | title = The incidence of yolk sac tumor (endodermal sinus tumor) elements in germ cell tumors of the testis in adults. | journal = Cancer | volume = 36 | issue = 1 | pages = 211-5 | month = Jul | year = 1975 | doi =  | PMID = 1203848 }}</ref>


Line 81: Line 82:


DDx:
DDx:
*[[Embryonal carcinoma]].
*[[Embryonal carcinoma]] - more [[nuclear atypia]], nuclei usually overlap and classically vesicular.
*[[Mixed germ cell tumour]].
*[[Mixed germ cell tumour]].


====Images====
===Images===
====Case 1====
<gallery>
<gallery>
Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|Yolk sac tumour. (WC/Nephron)
Image:Mixed_germ_cell_tumour_-_very_high_mag.jpg|Yolk sac tumour. (WC/Nephron)
</gallery>
</gallery>
www:
 
====Case 2====
<gallery>
Image: Yolk sac tumour with hyaline bodies -- intermed mag.jpg | YST with hyaline bodies - intermed. mag. (WC)
Image: Yolk sac tumour with hyaline bodies -- high mag.jpg | YST with hyaline bodies - high mag. (WC)
Image: Yolk sac tumour with hyaline bodies -- very high mag.jpg | YST with hyaline bodies - very high mag. (WC)
</gallery>
 
====Case 3====
<gallery>
Image: Yolk sac tumour -- low mag.jpg | YST - low mag. (WC)
Image: Yolk sac tumour -- intermed mag.jpg | YST - intermed. mag. (WC)
Image: Yolk sac tumour -- high mag.jpg | YST - high mag. (WC)
Image: Yolk sac tumour -- very high mag.jpg | YST - very high mag. (WC)
</gallery>
 
===www images===
*[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)].
*[http://webpathology.com/image.asp?case=34&n=6 Hepatoid Pattern (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=34&n=5 Schiller-Duval body (webpathology.com)].
Line 94: Line 112:
*[http://path.upmc.edu/cases/case152.html Yolk sac tumour - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case152.html Yolk sac tumour - case 1 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case492.html Yolk sac tumour - case 2 - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case492.html Yolk sac tumour - case 2 - several images (upmc.edu)].
*[http://www.moffitt.org/CCJRoot/v11n6/pdf/374.pdf Yolk sac tumour (moffitt.org)].<ref name=pmid15625525>{{Cite journal  | last1 = Sesterhenn | first1 = IA. | last2 = Davis | first2 = CJ. | title = Pathology of germ cell tumors of the testis. | journal = Cancer Control | volume = 11 | issue = 6 | pages = 374-87 | month =  | year =  | doi =  | PMID = 15625525 }}</ref>
*[http://www.moffitt.org/File%20Library/Main%20Nav/Research%20and%20Clinical%20Trials/Cancer%20Control%20Journal/v11n6/374.pdf Testicular germ cell tumours (moffitt.org)].<ref name=pmid15625525>{{Cite journal  | last1 = Sesterhenn | first1 = IA. | last2 = Davis | first2 = CJ. | title = Pathology of germ cell tumors of the testis. | journal = Cancer Control | volume = 11 | issue = 6 | pages = 374-87 | month =  | year =  | doi =  | PMID = 15625525 }}</ref>


==IHC==
==IHC==
Line 100: Line 118:
*OCT3 -ve.
*OCT3 -ve.
**Positive in [[seminoma]] and [[embryonal carcinoma]].
**Positive in [[seminoma]] and [[embryonal carcinoma]].
*Alpha-fetoprotein (abbreviated AFP) +ve.
*[[Alpha-fetoprotein]] (abbreviated AFP) +ve.
*Glypican 3 +ve.
*[[Glypican 3]] +ve.
**More sensitive than AFP.<ref name=pmid20438407>{{Cite journal  | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref>
**More sensitive than AFP.<ref name=pmid20438407>{{Cite journal  | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref>


Others:
Others:
*[[CK19]] +ve.<ref>{{Cite journal  | last1 = Bremmer | first1 = F. | last2 = Ströbel | first2 = P. | last3 = Hubertus | first3 = H. | last4 = Strecker | first4 = J. | last5 = Gaisa | first5 = N. | last6 = Strauß | first6 = A. | last7 = Schweyer | first7 = S. | last8 = Radzun | first8 = H-J. | last9 = Behnes | first9 = C-L | title = CK19 is a sensitive marker for yolk sac tumours of the testis. | journal = Diagnostic Pathology | volume = 10 | issue = 7 | pages = | month =  | year = 2015 | doi = 10.1186/s13000-015-0243-y | PMID =  | url = www.diagnosticpathology.org/content/10/1/7‎Cached }}</ref>
**Seminoma -ve, embryonal carcinoma -ve, [[GCNIS]] (ITGCN) -ve, normal testis -ve.
*Cytokeratin +ve.{{fact}}
*Cytokeratin +ve.{{fact}}
*CD30 -ve.
*CD30 -ve.
Line 110: Line 130:
*OCT3/4 -ve.
*OCT3/4 -ve.
*Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal  | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi =  | PMID = 89123 }}</ref>
*Alpha-1-antitrypsin +ve (abbreviated A1A).<ref name=pmid89123>{{Cite journal  | last1 = Beilby | first1 = JO. | last2 = Horne | first2 = CH. | last3 = Milne | first3 = GD. | last4 = Parkinson | first4 = C. | title = Alpha-fetoprotein, alpha-1-antitrypsin, and transferrin in gonadal yolk-sac tumours. | journal = J Clin Pathol | volume = 32 | issue = 5 | pages = 455-61 | month = May | year = 1979 | doi =  | PMID = 89123 }}</ref>
*[[CDX2]] +ve in 8 of 20 cases with YST (versus glypican-3).<ref name=pmid19578052>{{Cite journal  | last1 = Bing | first1 = Z. | last2 = Pasha | first2 = T. | last3 = Tomaszewski | first3 = JE. | last4 = Zhang | first4 = P. | title = CDX2 expression in yolk sac component of testicular germ cell tumors. | journal = Int J Surg Pathol | volume = 17 | issue = 5 | pages = 373-7 | month = Oct | year = 2009 | doi = 10.1177/1066896909338598 | PMID = 19578052 }}</ref>
*SOX2 -ve (0 of 17<ref name=pmid19369635>{{cite journal |authors=Nonaka D |title=Differential expression of SOX2 and SOX17 in testicular germ cell tumors |journal=Am J Clin Pathol |volume=131 |issue=5 |pages=731–6 |date=May 2009 |pmid=19369635 |doi=10.1309/AJCP7MNCNBCRN8NO |url=}}</ref>).
*SOX17 +ve (17 of 17 cases<ref name=pmid19369635/>).


==See also==
==See also==
Michael
48,453

edits

Retrieved from "https://librepathology.org/wiki/Special:MobileDiff/32945...52483"

Navigation menu