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'''Verrucous carcinoma''', also '''verrucous squamous cell carcinoma''', is an uncommon variant of [[squamous cell carcinoma]] that may be challenging to diagnose. | |||
==General== | |||
*Good prognosis. | |||
*Histomorphologically deceptively bland, i.e. non-malignant appearing. | |||
*Wart-like (verruca = [[wart]]). | |||
*The clinical history, e.g. ''huge verrucous cancer'', is often important for making the diagnosis. | |||
==Microscopic== | |||
Features: | |||
*Exophytic growth. | |||
*Well-differentiated. | |||
*"Glassy" appearance. | |||
*Pushing border - described "elephant feet". | |||
DDx: | |||
*[[Papilloma]]. | |||
*[[Wart]]. | |||
===Images=== | |||
<gallery> | |||
Image: Micrograph of penile verrucous carcinoma - 20x.jpg | Penile VC - Low Mag. (WC) | |||
Image: Micrograph of penile verrucous carcinoma - 200x.jpg | Penile VC - High Mag. (WC) | |||
</gallery> | |||
*[http://www.juniordentist.com/wp-content/uploads/2011/06/Verrucous-carcinoma-histology.jpg Verrucous carcinoma (juniordentist.com)].<ref>URL: [http://www.juniordentist.com/verrucous-carcinoma.html http://www.juniordentist.com/verrucous-carcinoma.html]. Accessed on: 3 April 2012.</ref> | |||
*[http://www.pathologyoutlines.com/images/prostate/psverrucous_scc_01.jpg Verrucous SCC (pathologyoutlines.com)]. | |||
==Sign out== | |||
===Biopsy=== | |||
<pre> | |||
Mouth Lesion, Hard Palate, Biopsy: | |||
- Squamous mucosa with keratinization and verrucous features, see comment. | |||
Comment: | |||
A clinic note describes a 2 cm mass of the hard palate. The clinical impression is noted. Correlation with imaging and the clinical features is recommended. | |||
</pre> | |||
====Micro==== | |||
The sections show superficial squamous mucosa with keratinization and church spire-like structures. Mild basal cellular changes are present. Significant epithelial nuclear atypia is absent. Minimal stroma with mild inflammation is present. | |||
==See also== | |||
*[[Squamous cell carcinoma]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||
[[Category:Head and neck pathology]] | |||