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Difference between revisions of "Vasitis nodosa"
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| Image = Vasitis nodosa -11- intermed mag.jpg | | Image = Vasitis nodosa -11- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = Vasitis nodosa. [[H&E stain]]. | | Caption = Vasitis nodosa (left side of image). [[H&E stain]]. | ||
| Micro = tubules with sperm | | Micro = tubules with sperm | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[prostate carcinoma]], metastatic [[adenocarcinoma]] | | LMDDx = [[prostate carcinoma]], metastatic [[adenocarcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = PSA -ve, PSAP -ve | | IHC = [[PSA]] -ve, PSAP -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 17: | Line 17: | ||
| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = previous [[vasectomy]] | | Clinicalhx = (usually) previous [[vasectomy]] | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
}} | |||
{{ Infobox external links | |||
| Name = {{PAGENAME}} | |||
| EHVSC = 10185 | |||
| pathprotocols = | |||
| wikipedia = | |||
| pathoutlines = | |||
}} | }} | ||
'''Vasitis nodosa''', abbreviated '''VN''', is a common complication of [[vasectomy]] that is seldomly seen by pathologists. It is seen by pathologists in the context of vasovasostomy. | '''Vasitis nodosa''', abbreviated '''VN''', is a common complication of [[vasectomy]] that is seldomly seen by pathologists. It is seen by pathologists in the context of vasovasostomy. | ||
==General== | ==General== | ||
*Classically | *Classically seen in a specimen from a vasovasostomy ([[vasectomy]] reversal).<ref name=pmid3366928>{{Cite journal | last1 = Hirschowitz | first1 = L. | last2 = Rode | first2 = J. | last3 = Guillebaud | first3 = J. | last4 = Bounds | first4 = W. | last5 = Moss | first5 = E. | title = Vasitis nodosa and associated clinical findings. | journal = J Clin Pathol | volume = 41 | issue = 4 | pages = 419-23 | month = Apr | year = 1988 | doi = | PMID = 3366928 | PMC=1141468 }}</ref> | ||
**Seen in association with other surgical procedures. | **Seen in association with other surgical procedures. | ||
**May be seen in the context of infertility (without prior vasectomy). | **May be seen in the context of infertility (without prior vasectomy). | ||
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**May "invade" vascular spaces - associated with elastosis (breakdown of elastic fibres<ref>URL: [http://medical-dictionary.thefreedictionary.com/elastosis http://medical-dictionary.thefreedictionary.com/elastosis]. Accessed on: 26 September 2011.</ref>). | **May "invade" vascular spaces - associated with elastosis (breakdown of elastic fibres<ref>URL: [http://medical-dictionary.thefreedictionary.com/elastosis http://medical-dictionary.thefreedictionary.com/elastosis]. Accessed on: 26 September 2011.</ref>). | ||
=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: Vasitis nodosa -11- intermed mag.jpg | VN - intermed. mag. (WC) | Image: Vasitis nodosa -11- intermed mag.jpg | VN - intermed. mag. (WC) | ||
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www: | www: | ||
*[http://www.webpathology.com/image.asp?n=11&Case=40 Vasitis nodosa (webpathology.com)]. | *[http://www.webpathology.com/image.asp?n=11&Case=40 Vasitis nodosa (webpathology.com)]. | ||
*[http://www.flickr.com/photos/lunarcaustic/6938362234/ Vasitis nodosa (flickr.com/lunar caustic)]. | |||
==IHC== | ==IHC== | ||
*PSA -ve. | Features:<ref name=pmid10843416>{{Cite journal | last1 = Sakaki | first1 = M. | last2 = Hirokawa | first2 = M. | last3 = Horiguchi | first3 = H. | last4 = Wakatsuki | first4 = S. | last5 = Sano | first5 = T. | title = Vasitis nodosa: immunohistochemical findings--case report. | journal = APMIS | volume = 108 | issue = 4 | pages = 283-6 | month = Apr | year = 2000 | doi = | PMID = 10843416 }} | ||
*PSAP -ve. | </ref> | ||
*[[PSA]] -ve. | |||
*[[CK7]] +ve | |||
*[[CK34betaE12]] +ve. | |||
*Vimentin +ve. | |||
*CK19 +ve. | |||
Others: | |||
*[[PSAP]] -ve. | |||
==Sign out== | ==Sign out== | ||
<pre> | |||
Right Vas Deferens, Excision: | |||
- Vasitis nodosa. | |||
</pre> | |||
===Block letters=== | |||
<pre> | <pre> | ||
A. VAS DEFERENS WITH GRANULOMA, RIGHT, VASOVASOSTOMY: | A. VAS DEFERENS WITH GRANULOMA, RIGHT, VASOVASOSTOMY: | ||
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- COMPLETE CROSS SECTION OF VAS DEFERENS. | - COMPLETE CROSS SECTION OF VAS DEFERENS. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show one unremarkable cross section of the vas deferens and several sections with a histocytic response at the external aspect of the vas deferens' muscle layers. The histocytes are aggregated and contains bland tubular structures with sperm. | |||
The tubular structures are POSITIVE for CK7 and CK34betaE12, and NEGATIVE for PSA. CD68 marks the histiocytes. | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist|2} | {{Reflist|2}} | ||
[[Category:Genitourinary pathology]] | [[Category:Genitourinary pathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||