Difference between revisions of "Vasculitides"

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Vasculitides (view source)

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*Polyarteritis nodosa (PAN).
*Polyarteritis nodosa (PAN).
*Microscopic polyangiitis.
*Microscopic polyangiitis.
*Wegener's granulomatosis.
*Granulomatosis with polyangiitis (Wegener's granulomatosis).
*Predominantly cutaneous vasculitis.
*Predominantly cutaneous vasculitis.
*Giant cell arteritis (GCA).
*Giant cell arteritis (GCA).
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*Essential cryoglobulinemic vasculitis.
*Essential cryoglobulinemic vasculitis.
*ANCA-associated:
*ANCA-associated:
**[[Wegener's granulomatosis]] (c-ANCA > p-ANCA).
**[[Granulomatosis with polyangiitis]] (Wegener's granulomatosis) - c-ANCA > p-ANCA.
**[[Churg-Strauss syndrome]] (50% ANCA +ve).
**[[Eosinophilic granulomatosis with polyangiitis]] (Churg-Strauss syndrome) - 50% ANCA +ve.
**[[Microscopic polyangiitis]] (usually p-ANCA).
**[[Microscopic polyangiitis]] - usually p-ANCA.


Notes:
Notes:
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*Giant cell arteritis.
*Giant cell arteritis.
*Takayasu arteritis.
*Takayasu arteritis.
*Churg-Strauss disease.
*Eosinophilic granulomatosis with polyangiitis (Churg-Strauss disease).
*Wegener’s granulomatosis.
*Granulomatosis with polyangiitis (Wegener’s granulomatosis).


Note:
Note:
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==Granulomatosis with polyangiitis==
==Granulomatosis with polyangiitis==
*[[AKA]] ''Wegener granulomatosis''.
:Previously known as ''Wegener granulomatosis''.
{{Main|Granulomatosis with polyangiitis}}
{{Main|Granulomatosis with polyangiitis}}


==Churg-Strauss syndrome==
==Eosinophilic granulomatosis with polyangiitis==
*Abbreviated ''CSS''.
:Previously known as ''Churg-Strauss syndrome'' and ''Churg-Strauss disease''.
*AKA ''allergic granulomatous angiitis''.<ref name=emedicine333492>[http://emedicine.medscape.com/article/333492-overview http://emedicine.medscape.com/article/333492-overview]</ref>
{{Main|Eosinophilic granulomatosis with polyangiitis}}
*[[AKA]] ''Churg-Strauss disease''.


===General===
Defining features - memory device ''GAFE'':
*'''G'''ranulomata.
*'''A'''sthma.
*'''F'''ever.
*'''E'''osinophilia.
Notes:
*Similar to ''[[Wegener's granulomatosis]]'' (classically c-ANCA +ve) and ''microscopic polyangiitis''.<ref>URL: [http://emedicine.medscape.com/article/334024-overview http://emedicine.medscape.com/article/334024-overview]. Accessed on: 22 January 2011.</ref>
===Microscopic===
Features:
*Small vessel [[vasculitis]].
*Abundant eosinophils.
*[[Granuloma]]s.
DDx:
*Eosinophilic vasculitis associated with a [[connective tissue disease]].<ref name=pmid8708015>{{Cite journal  | last1 = Chen | first1 = KR. | last2 = Su | first2 = WP. | last3 = Pittelkow | first3 = MR. | last4 = Conn | first4 = DL. | last5 = George | first5 = T. | last6 = Leiferman | first6 = KM. | title = Eosinophilic vasculitis in connective tissue disease. | journal = J Am Acad Dermatol | volume = 35 | issue = 2 Pt 1 | pages = 173-82 | month = Aug | year = 1996 | doi =  | PMID = 8708015 }}</ref>
====Images====
<gallery>
Image:Churg-Strauss_syndrome_-_high_mag.jpg |CSS - high mag. (WC)
Image:Churg-Strauss_syndrome_-_very_high_mag.jpg |CSS - very high mag. (WC)
</gallery>
=Medium vessel vasculitides=
=Medium vessel vasculitides=
The follow section has information specific to the individual types of medium vessel vasculitis.
The follow section has information specific to the individual types of medium vessel vasculitis.
Michael
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