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Difference between revisions of "Urothelial dysplasia"
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==IHC== | ==IHC== | ||
A comparison between benign, dysplasia and [[UCIS]]:<ref name=pmid12640096>{{Cite journal | last1 = Mallofré | first1 = C. | last2 = Castillo | first2 = M. | last3 = Morente | first3 = V. | last4 = Solé | first4 = M. | title = Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 187-91 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056628.38714.5D | PMID = 12640096 }}</ref> | A comparison between benign, dysplasia and [[UCIS]]:<ref name=pmid12640096>{{Cite journal | last1 = Mallofré | first1 = C. | last2 = Castillo | first2 = M. | last3 = Morente | first3 = V. | last4 = Solé | first4 = M. | title = Immunohistochemical expression of CK20, p53, and Ki-67 as objective markers of urothelial dysplasia. | journal = Mod Pathol | volume = 16 | issue = 3 | pages = 187-91 | month = Mar | year = 2003 | doi = 10.1097/01.MP.0000056628.38714.5D | PMID = 12640096 }}</ref> | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
| Line 84: | Line 80: | ||
! Ki-67 | ! Ki-67 | ||
! p53 | ! p53 | ||
! p63 ‡ | |||
|- | |- | ||
| Benign (reactive) | | Benign (reactive) | ||
| Line 89: | Line 86: | ||
| -ve <=10% of cells (+/-rare basal cells) | | -ve <=10% of cells (+/-rare basal cells) | ||
| -ve <20% of cells (+/-weak staining) | | -ve <20% of cells (+/-weak staining) | ||
| -ve surface cells | |||
|- | |- | ||
| Urothelial dysplasia | | Urothelial dysplasia | ||
| Line 94: | Line 92: | ||
| +ve >10% of cells (~40% of cases) | | +ve >10% of cells (~40% of cases) | ||
| +ve >=20% of cells (~70% of cases) | | +ve >=20% of cells (~70% of cases) | ||
| -ve surface cells<ref name=pmid19690775>{{Cite journal | last1 = Stepan | first1 = A. | last2 = Mărgăritescu | first2 = C. | last3 = Simionescu | first3 = C. | last4 = Ciurea | first4 = R. | title = E-cadherin and p63 immunoexpression in dysplastic lesions and urothelial carcinomas of the bladder. | journal = Rom J Morphol Embryol | volume = 50 | issue = 3 | pages = 461-5 | month = | year = 2009 | doi = | PMID = 19690775 }}</ref><ref name=OJP>{{Cite journal | last1 = Raheem| first1 = Sayad A.| last2 = Saied | first2 = Abdel N. | last3 = Al Shaer | first3 = Rabee | last4 = Mustafa | first4 = Osama | last5 = Ali | first5 = Ali H. | title = The Role of CK20, p53 and p63 in Differentiation of Some Urothelial Lesions of Urinary Bladder, Immunohistochemical Study | journal = [http://www.scirp.org/journal/ojpathology Open Journal of Pathology] | volume = | issue = 4| pages = 181-193 | month = | year = 2014 | doi = 10.4236/ojpathology.2014.44024 | PMID = | PMC = | url = }}</ref> | |||
|- | |- | ||
| [[Urothelial carcinoma in situ|Urothelial carcinoma in situ]] (UCIS | | [[Urothelial carcinoma in situ|Urothelial carcinoma in situ]] (UCIS) | ||
| +ve non-umbrella cells (~70% of cases) | | +ve non-umbrella cells (~70% of cases) | ||
| +ve >10% of cells (~95% of cases) | | +ve >10% of cells (~95% of cases) | ||
| +ve >=20% of cells (~80% of cases) | | +ve >=20% of cells (~80% of cases) | ||
| +ve surface cells<ref name=pmid19690775/><ref name=OJP/> | |||
|} | |} | ||
Note: | Note: | ||
*Morphology is considered the gold standard for UCIS versus urothelial dysplasia | *‡ Morphology is considered the gold standard for UCIS versus urothelial dysplasia;{{fact}} however, there is a small literature on [[p63]] for dysplasia versus UCIS that is published in lesser known journals. | ||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
A. RIGHT URETER (MARGIN), EXCISION: | Urinary Bladder, Biopsy: | ||
- UROTHELIAL DYSPLASIA, SEE COMMENT. | - Urothelial dysplasia, see comment. | ||
- NEGATIVE FOR UROTHELIAL CARCINOMA. | - Giant cell reaction and chronic inflammation. | ||
Comment: | |||
The urothelium has moderate CK20 staining that extends to the basement membrane. A p53 stain is negative (<10% staining). A Ki-67 stain shows increased staining (marks 20% of urothelium). A p63 stain shows weak/negative surface staining. | |||
</pre> | |||
===Block letters=== | |||
<pre> | |||
RIGHT URETER (MARGIN), EXCISION: | |||
- UROTHELIAL DYSPLASIA, SEE COMMENT. | |||
- NEGATIVE FOR UROTHELIAL CARCINOMA. | |||
COMMENT: | COMMENT: | ||