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Difference between revisions of "Urine cytopathology"
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[[Image:Benign urine cytology - 2a -- very high mag.jpg|thumb|right|Urine cytology - squamous cells and urothelial cells. (WC)]] | |||
[[Image:Benign urine cytology - 3b -- very high mag.jpg|thumb|right|Urine cytology. (WC)]] | |||
[[Image:Benign urine cytology - 4 -- very high mag.jpg|thumb|right|Urine cytology. (WC)]] | |||
'''Urine cytopathology''' is a large part of cytopathology. | '''Urine cytopathology''' is a large part of cytopathology. | ||
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**Usually contamination from gential tract (in females). | **Usually contamination from gential tract (in females). | ||
=== | ===Paris system for urinary cytology=== | ||
This is a reporting standard with the following categories:<ref name=pmid27318895>{{Cite journal | last1 = Barkan | first1 = GA. | last2 = Wojcik | first2 = EM. | last3 = Nayar | first3 = R. | last4 = Savic-Prince | first4 = S. | last5 = Quek | first5 = ML. | last6 = Kurtycz | first6 = DF. | last7 = Rosenthal | first7 = DL. | title = The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology. | journal = Acta Cytol | volume = 60 | issue = 3 | pages = 185-97 | month = | year = 2016 | doi = 10.1159/000446270 | PMID = 27318895 }}</ref> | |||
#Nondiagnostic/unsatisfactory | #Nondiagnostic/unsatisfactory | ||
#Negative for [[ | #Negative for [[urothelial carcinoma|high-grade urothelial carcinoma]] | ||
#Atypical urothelial cells | #Atypical urothelial cells | ||
#Suspicous for | #Suspicous for high-grade urothelial carcinoma | ||
# | #High-grade urothelial carcinoma | ||
#Low grade urothelial neoplasm | #Low-grade urothelial neoplasm | ||
#Other malignancy | #Other malignancy (includes both primary and secondary) and miscellaneous lesions | ||
==Normal== | ==Normal== | ||
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*Benign cells are often in small clumps. | *Benign cells are often in small clumps. | ||
=== | ===Major cell types=== | ||
Practical cell typing:<ref>SM. 7 January 2010.</ref> | Practical cell typing:<ref>SM. 7 January 2010.</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
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| Irregular/jagged | | Irregular/jagged | ||
|} | |} | ||
====Images==== | |||
=====Case 1===== | |||
<gallery> | |||
Image: Benign urine cytology - 4 -- very high mag.jpg | Benign - c/w renal tubular cells - very high mag. (WC) | |||
Image: Benign urine cytology - 4 - alt -- very high mag.jpg | Benign - c/w renal tubular cells - very high mag. (WC) | |||
</gallery> | |||
=====Case 2===== | |||
<gallery> | |||
Image: Benign urine cytology - 1 -- very high mag.jpg | BUC - very high mag. (WC) | |||
Image: Benign urine cytology - 1a -- very high mag.jpg | BUC - very high mag. (WC) | |||
Image: Benign urine cytology - 1b -- very high mag.jpg | BUC - very high mag. (WC) | |||
</gallery> | |||
=====Case 3===== | |||
<gallery> | |||
Image: Benign urine cytology - 3 -- high mag.jpg | BUC - high mag. (WC) | |||
Image: Benign urine cytology - 3a -- very high mag.jpg | BUC - very high mag. (WC) | |||
Image: Benign urine cytology - 3b -- very high mag.jpg | BUC - very high mag. (WC) | |||
</gallery> | |||
=====Case 4===== | |||
<gallery> | |||
Image: Benign urine cytology - 2 -- high mag.jpg | BUC - high mag. | |||
Image: Benign urine cytology - 2a -- very high mag.jpg | BUC - very high mag. | |||
Image: Benign urine cytology - 2x -- very high mag.jpg | BUC - very high mag. | |||
Image: Benign urine cytology - 2i -- very high mag.jpg | BUC - very high mag. | |||
</gallery> | |||
===Degenerative cells=== | ===Degenerative cells=== | ||
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*Vacuolated cytoplasm - "moth-eaten" appearance. | *Vacuolated cytoplasm - "moth-eaten" appearance. | ||
**Normal urothelial cytoplasm is dense and has no vacuoles. | **Normal urothelial cytoplasm is dense and has no vacuoles. | ||
===Urine crystals=== | |||
{{Main|Urine crystals}} | |||
==Tabular DDx== | ==Tabular DDx== | ||
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*Associated with immunosuppression/immunodeficiency. | *Associated with immunosuppression/immunodeficiency. | ||
*BK virus related to JC virus. | *BK virus related to JC virus. | ||
*BK virus associated with [[urothelial carcinoma]].<ref name=pmid24879380>{{Cite journal | last1 = Tsai | first1 = HL. | last2 = Chang | first2 = JW. | last3 = Wu | first3 = TH. | last4 = King | first4 = KL. | last5 = Yang | first5 = LY. | last6 = Chan | first6 = YJ. | last7 = Yang | first7 = AH. | last8 = Chang | first8 = FP. | last9 = Pan | first9 = CC. | title = Outcomes of kidney transplant tourism and risk factors for de novo urothelial carcinoma. | journal = Transplantation | volume = 98 | issue = 1 | pages = 79-87 | month = Jul | year = 2014 | doi = 10.1097/TP.0000000000000023 | PMID = 24879380 }}</ref><ref name=pmid24103071>{{Cite journal | last1 = Li | first1 = JY. | last2 = Fang | first2 = D. | last3 = Yong | first3 = TY. | last4 = Klebe | first4 = S. | last5 = Juneja | first5 = R. | last6 = Gleadle | first6 = JM. | title = Transitional cell carcinoma in a renal allograft with BK nephropathy. | journal = Transpl Infect Dis | volume = 15 | issue = 6 | pages = E270-2 | month = Dec | year = 2013 | doi = 10.1111/tid.12142 | PMID = 24103071 }}</ref> | |||
DDx: | DDx: | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
==External links== | |||
*[http://www.cytologystuff.com/study/nongynintro3.htm Urine cytology (cytologystuff.com)]. | |||
[[Category:Cytopathology]] | [[Category:Cytopathology]] | ||