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Difference between revisions of "Urinary bladder xanthoma"
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Urinary bladder xanthoma (view source)
Revision as of 14:57, 4 November 2022
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Urinary_bladder_xanthoma_--_intermed_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Urinary bladder xanthoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = aggregate of foamy histiocytes in the lamina propria, no significant nuclear atypia | | Micro = aggregate of foamy histiocytes in the lamina propria, no significant nuclear atypia | ||
| Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[urinary bladder]] | | Site = [[urinary bladder]] and other sites - see ''[[xanthoma]]'' | ||
| Assdx = lipid disorders (hyperlipidemia) | | Assdx = lipid disorders (hyperlipidemia) | ||
| Syndromes = | | Syndromes = | ||
| Line 30: | Line 30: | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Urinary bladder xanthoma''', also '''[[xanthoma]] of the | '''Urinary bladder xanthoma''', also '''[[xanthoma]] of the urinary bladder''' and '''bladder xanthoma''', is a rare benign lesion of the [[urinary bladder|bladder]] that occasionally may be clinically suspicious for [[malignancy]].<ref name=pmid24810457>{{Cite journal | last1 = Hassouna | first1 = H. | last2 = Broome | first2 = JD. | last3 = Swalem | first3 = K. | last4 = Manikandan | first4 = R. | title = Xanthoma of the urinary bladder: a rare benign condition which may be mistaken for malignancy. | journal = BMJ Case Rep | volume = 2014 | issue = | pages = | month = | year = 2014 | doi = 10.1136/bcr-2014-203836 | PMID = 24810457 }}</ref> | ||
==General== | ==General== | ||
*Rare. | *Rare - 17 cases in a larger multi-institutional study.<ref name=pmid25580863/> | ||
*Like other [[xanthoma]]s may be associated with abnormal lipid profile. | *Like other [[xanthoma]]s may be associated with an abnormal lipid profile. | ||
Presentation:<ref name=pmid25580863>{{Cite journal | last1 = Yu | first1 = DC. | last2 = Patel | first2 = P. | last3 = Bonert | first3 = M. | last4 = Carlson | first4 = K. | last5 = Yilmaz | first5 = A. | last6 = Paner | first6 = G. | last7 = Magi-Galluzzi | first7 = C. | last8 = Lopez-Beltran | first8 = A. | last9 = Trpkov | first9 = K. | title = Urinary bladder xanthoma: a multi-institutional series of 17 cases. | journal = Histopathology | volume = 67 | issue = 2 | pages = 255-61 | month = Aug | year = 2015 | doi = 10.1111/his.12647 | PMID = 25580863 }}</ref> | Presentation:<ref name=pmid25580863>{{Cite journal | last1 = Yu | first1 = DC. | last2 = Patel | first2 = P. | last3 = Bonert | first3 = M. | last4 = Carlson | first4 = K. | last5 = Yilmaz | first5 = A. | last6 = Paner | first6 = G. | last7 = Magi-Galluzzi | first7 = C. | last8 = Lopez-Beltran | first8 = A. | last9 = Trpkov | first9 = K. | title = Urinary bladder xanthoma: a multi-institutional series of 17 cases. | journal = Histopathology | volume = 67 | issue = 2 | pages = 255-61 | month = Aug | year = 2015 | doi = 10.1111/his.12647 | PMID = 25580863 }}</ref> | ||
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*[[Xanthogranulomatous cystitis]]. | *[[Xanthogranulomatous cystitis]]. | ||
*Mild urothelial atypia (esp. large umbrella cells) in normal [[urothelium]]. | *Mild urothelial atypia (esp. large umbrella cells) in normal [[urothelium]]. | ||
===Images=== | |||
<gallery> | |||
Image: Urinary bladder xanthoma -- low mag.jpg | UBX - low mag. | |||
Image: Urinary bladder xanthoma -- intermed mag.jpg | UBX - intermed. mag. | |||
Image: Urinary bladder xanthoma -- high mag.jpg | UBX - high mag. | |||
Image: Urinary bladder xanthoma -- very high mag.jpg | UBX - very high mag. | |||
Image: Urinary bladder xanthoma - alt -- intermed mag.jpg | UBX - intermed. mag. | |||
Image: Urinary bladder xanthoma - alt -- high mag.jpg | UBX - high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
| Line 68: | Line 79: | ||
COMMENT: | COMMENT: | ||
These lesions may be associated metabolic abnormalities. A lipid profile | These lesions may be associated with metabolic abnormalities. A lipid | ||
profile is suggested if not done recently. | |||
</pre> | </pre> | ||