Urinary bladder metastasis

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Urinary bladder metastasis
Diagnosis in short

Clear cell renal cell carcinoma metastasis to urinary bladder. H&E stain.

Synonyms metastasis to urinary bladder
LM DDx urothelial carcinoma with unusual features, primary adenocarcinoma of the urinary bladder, direct extension of non-bladder primary tumour in bladder (e.g. prostate, rectum, urachal carcinoma)
IHC GATA3 -ve/+ve (commonly +ve in breast), beta-catenin +ve/-ve (nuclear staining - suggests colorectal primary), prostate markers (e.g. PSA, PSAP, NKX3.1) +ve/-ve (+ve suggests prostate primary), PAX8 +ve/-ve (+ve suggests gyne tract or RCC)
Site urinary bladder

Clinical history +/-history of cancer
Symptoms hematuria (typical)
Prevalence rare as primary presentation (case reports)
Endoscopy bladder tumour
Prognosis poor
Clin. DDx primary bladder cancer
Treatment dependent on primary site

Urinary bladder metastasis, also metastasis to the bladder, is cancer that has spread to the urinary bladder from another primary site and is discontinuous with the primary tumour.


A 2007 review of the literature found:[5]

  • 264 reported cases from 1953 to June 2005 - most from GU tract and the colorectum.
    • Distant site includes breast, stomach and melanoma.



  • Dependent on the primary site.



See also


  1. Zhang, M.; Wah, C.; Epstein, JI. (Nov 2014). "Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.". Am J Surg Pathol 38 (11): 1516-21. doi:10.1097/PAS.0000000000000257. PMID 25140895.
  2. Avargues, A.; Luján, S.; Palomar, L.; Rogel, R.; Broseta, E.; Boronat, F. (Oct 2015). "[Metastatic urinary bladder involvement in breast cancer].". Arch Esp Urol 68 (8): 676-8. PMID 26437333.
  3. Al Ibraheemi, AA. (Jan 2016). "Case report of metastatic invasive breast lobular carcinoma to the urinary bladder.". Int J Hematol Oncol Stem Cell Res 10 (1): 51-5. PMID 27047651.
  4. Wong, MH.; Yiu, MK.; Ho, KL. (Oct 2013). "Metastatic carcinoma of breast in the urinary bladder.". Hong Kong Med J 19 (5): 455-7. PMID 24088591.
  5. Velcheti, V.; Govindan, R. (Feb 2007). "Metastatic cancer involving bladder: a review.". Can J Urol 14 (1): 3443-8. PMID 17324324.