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Urinary bladder metastasis (view source)
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'''Urinary bladder metastasis''' is [[cancer]] that has spread to the [[urinary bladder]] from another primary site and is discontinuous with the primary tumour. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Clear cell renal cell carcinoma metastasis to bladder -- intermed mag.jpg | |||
| Width = | |||
| Caption = Clear cell renal cell carcinoma metastasis to urinary bladder. [[H&E stain]]. | |||
| Synonyms = metastasis to urinary bladder | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[urothelial carcinoma]] with unusual features, [[primary adenocarcinoma of the urinary bladder]], direct extension of non-bladder primary tumour in bladder (e.g. [[prostate cancer|prostate]], rectum, [[urachal carcinoma]]) | |||
| Stains = | |||
| IHC = [[GATA3]] -ve/+ve (commonly +ve in breast), beta-catenin +ve/-ve (nuclear staining - suggests colorectal primary), prostate markers (e.g. PSA, PSAP, NKX3.1) +ve/-ve (+ve suggests prostate primary), PAX8 +ve/-ve (+ve suggests gyne tract or RCC) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[urinary bladder]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-history of cancer | |||
| Signs = | |||
| Symptoms = hematuria (typical) | |||
| Prevalence = rare as primary presentation (case reports) | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = bladder tumour | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = primary bladder cancer | |||
| Tx = dependent on primary site | |||
}} | |||
'''Urinary bladder metastasis''', also '''metastasis to the bladder''', is [[cancer]] that has spread to the [[urinary bladder]] from another primary site and is discontinuous with the primary tumour. | |||
==General== | ==General== | ||
*Rare - mostly case reports. | *Rare - mostly case reports. | ||
**[[Renal cell carcinoma]] ~ series of 11 cases.<ref name=pmid25140895>{{Cite journal | last1 = Zhang | first1 = M. | last2 = Wah | first2 = C. | last3 = Epstein | first3 = JI. | title = Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1516-21 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000257 | PMID = 25140895 }}</ref> | **[[Renal cell carcinoma]] ~ series of 11 cases.<ref name=pmid25140895>{{Cite journal | last1 = Zhang | first1 = M. | last2 = Wah | first2 = C. | last3 = Epstein | first3 = JI. | title = Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1516-21 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000257 | PMID = 25140895 }}</ref> | ||
**Breast primary - small series<ref name=pmid26437333>{{Cite journal | last1 = Avargues | first1 = A. | last2 = Luján | first2 = S. | last3 = Palomar | first3 = L. | last4 = Rogel | first4 = R. | last5 = Broseta | first5 = E. | last6 = Boronat | first6 = F. | title = [Metastatic urinary bladder involvement in breast cancer]. | journal = Arch Esp Urol | volume = 68 | issue = 8 | pages = 676-8 | month = Oct | year = 2015 | doi = | PMID = 26437333 }}</ref> and case reports.<ref name=pmid27047651>{{Cite journal | last1 = Al Ibraheemi | first1 = AA. | title = Case report of metastatic invasive breast lobular carcinoma to the urinary bladder. | journal = Int J Hematol Oncol Stem Cell Res | volume = 10 | issue = 1 | pages = 51-5 | month = Jan | year = 2016 | doi = | PMID = 27047651 }}</ref><ref name=pmid24088591>{{Cite journal | last1 = Wong | first1 = MH. | last2 = Yiu | first2 = MK. | last3 = Ho | first3 = KL. | title = Metastatic carcinoma of breast in the urinary bladder. | journal = Hong Kong Med J | volume = 19 | issue = 5 | pages = 455-7 | month = Oct | year = 2013 | doi = | PMID = 24088591 }}</ref> | |||
A 2007 review of the literature found:<ref name=pmid17324324>{{Cite journal | last1 = Velcheti | first1 = V. | last2 = Govindan | first2 = R. | title = Metastatic cancer involving bladder: a review. | journal = Can J Urol | volume = 14 | issue = 1 | pages = 3443-8 | month = Feb | year = 2007 | doi = | PMID = 17324324 }}</ref> | |||
*264 reported cases from 1953 to June 2005 - most from GU tract and the colorectum. | |||
**Distant site includes [[breast cancer|breast]], stomach and melanoma. | |||
==Microscopic== | ==Microscopic== | ||
| Line 13: | Line 50: | ||
*[[Primary adenocarcinoma of the urinary bladder]]. | *[[Primary adenocarcinoma of the urinary bladder]]. | ||
*[[Urachal carcinoma]]. | *[[Urachal carcinoma]]. | ||
*Direct extension of primary tumour from other primary site, e.g. prostate, rectum. | *Direct extension of primary tumour from other primary site, e.g. [[prostate cancer|prostate]], rectum. | ||
===Images=== | ===Images=== | ||
| Line 22: | Line 59: | ||
Image: Clear cell renal cell carcinoma metastasis to bladder -- high mag.jpg | CCRCC in bladder - high mag. (WC) | Image: Clear cell renal cell carcinoma metastasis to bladder -- high mag.jpg | CCRCC in bladder - high mag. (WC) | ||
</gallery> | </gallery> | ||
==See also== | |||
*[[Metastasis]]. | |||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||