Difference between revisions of "Urinary bladder amyloidosis"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Urinary bladder amyloidosis -- low mag.jpg
| Width      =
| Caption    = Urinary bladder amyloidosis. [[H&E stain]].
| Synonyms  = amyloidosis of the urinary bladder
| Micro      = lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked")
| Subtypes  =
| LMDDx      = fibrosis, fibrin, [[leiomyoma]]
| Stains    = [[Congo red]] +ve
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[urinary bladder]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      = thickened bladder wall
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    = other urinary bladder tumours - esp. malignant ones
| Tx        =
}}
'''Urinary bladder amyloidosis''', more formally '''primary urinary bladder amyloidosis''', is a rare benign condition of [[urinary bladder]] that can mimic [[cancer]] of the [[urinary bladder]].<ref name=pmid25366012>{{Cite journal  | last1 = Kobayashi | first1 = T. | last2 = Roberts | first2 = J. | last3 = Levine | first3 = J. | last4 = Degrado | first4 = J. | title = Primary bladder amyloidosis. | journal = Intern Med | volume = 53 | issue = 21 | pages = 2511-3 | month =  | year = 2014 | doi =  | PMID = 25366012 }}</ref>
'''Urinary bladder amyloidosis''', more formally '''primary urinary bladder amyloidosis''', is a rare benign condition of [[urinary bladder]] that can mimic [[cancer]] of the [[urinary bladder]].<ref name=pmid25366012>{{Cite journal  | last1 = Kobayashi | first1 = T. | last2 = Roberts | first2 = J. | last3 = Levine | first3 = J. | last4 = Degrado | first4 = J. | title = Primary bladder amyloidosis. | journal = Intern Med | volume = 53 | issue = 21 | pages = 2511-3 | month =  | year = 2014 | doi =  | PMID = 25366012 }}</ref>


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*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>
*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>
**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal  | last1 = Schou-Jensen | first1 = KS. | last2 = Dahl | first2 = C. | last3 = Pilt | first3 = AP. | last4 = Azawi | first4 = NH. | title = Amyloidosis in the bladder: three cases with different appearance. | journal = Scand J Urol | volume = 48 | issue = 5 | pages = 489-92 | month = Oct | year = 2014 | doi = 10.3109/21681805.2014.920414 | PMID = 24857645 }}</ref>
**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal  | last1 = Schou-Jensen | first1 = KS. | last2 = Dahl | first2 = C. | last3 = Pilt | first3 = AP. | last4 = Azawi | first4 = NH. | title = Amyloidosis in the bladder: three cases with different appearance. | journal = Scand J Urol | volume = 48 | issue = 5 | pages = 489-92 | month = Oct | year = 2014 | doi = 10.3109/21681805.2014.920414 | PMID = 24857645 }}</ref>
*May clinically mimic bladder cancer.<ref name=pmid25366012/>
*May clinically mimic [[bladder cancer]].<ref name=pmid25366012/>


==Gross==
==Gross==
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==Microscopic==
==Microscopic==
Features:
Features:
*Lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked").
*Lamina propria with amyloid.
**Amyloid = amorphous, paucicellular material that is [[pink on H&E]], classically has "cracked" appearance.
***"Cracked": irregular fragments where the edges and centre of fragments are homogeneous.
 
DDx:
*Fibrin.
*Fibrosis.
*[[Leiomyoma]].
 
===Images===
<gallery>
Image: Urinary bladder amyloidosis -- very low mag.jpg | UBA - very low mag. (WC)
Image: Urinary bladder amyloidosis -- low mag.jpg | UBA - low mag. (WC)
Image: Urinary bladder amyloidosis -- intermed mag.jpg | UBA - intermed. mag. (WC)
Image: Urinary bladder amyloidosis -- high mag.jpg | UBA - high mag. (WC)
</gallery>


==Stains==
==Stains==
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- Benign muscularis propria present.
- Benign muscularis propria present.
- NEGATIVE for urothelial carcinoma in situ.
- NEGATIVE for urothelial carcinoma in situ.
- NEGATIVE for malignancy.
- NEGATIVE for evidence of malignancy.


Comment:  
Comment:  
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Genitourinary pathology]]
[[Category:Genitourinary pathology]]

Latest revision as of 03:44, 23 October 2015

Urinary bladder amyloidosis
Diagnosis in short

Urinary bladder amyloidosis. H&E stain.

Synonyms amyloidosis of the urinary bladder

LM lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked")
LM DDx fibrosis, fibrin, leiomyoma
Stains Congo red +ve
Site urinary bladder

Prevalence very rare
Radiology thickened bladder wall
Clin. DDx other urinary bladder tumours - esp. malignant ones

Urinary bladder amyloidosis, more formally primary urinary bladder amyloidosis, is a rare benign condition of urinary bladder that can mimic cancer of the urinary bladder.[1]

General

Gross

  • Urinary bladder wall thickening.[1]

Microscopic

Features:

  • Lamina propria with amyloid.
    • Amyloid = amorphous, paucicellular material that is pink on H&E, classically has "cracked" appearance.
      • "Cracked": irregular fragments where the edges and centre of fragments are homogeneous.

DDx:

Images

Stains

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Urinary Bladder, Transurethral Resection:
- Urothelial mucosa with amyloidosis and mild chronic inflammation.
- Benign muscularis propria present.
- NEGATIVE for urothelial carcinoma in situ.
- NEGATIVE for evidence of malignancy.

Comment: 
Congo red staining and polarization confirm the presence of amyloid.

Primary bladder amyloidosis is rare; systemic causes of amyloidosis should 
be considered.

See also

References

  1. 1.0 1.1 1.2 1.3 Kobayashi, T.; Roberts, J.; Levine, J.; Degrado, J. (2014). "Primary bladder amyloidosis.". Intern Med 53 (21): 2511-3. PMID 25366012.
  2. 2.0 2.1 Schou-Jensen, KS.; Dahl, C.; Pilt, AP.; Azawi, NH. (Oct 2014). "Amyloidosis in the bladder: three cases with different appearance.". Scand J Urol 48 (5): 489-92. doi:10.3109/21681805.2014.920414. PMID 24857645.