Difference between revisions of "Urinary bladder amyloidosis"

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==General==
==General==
*Rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645>{{Cite journal  | last1 = Schou-Jensen | first1 = KS. | last2 = Dahl | first2 = C. | last3 = Pilt | first3 = AP. | last4 = Azawi | first4 = NH. | title = Amyloidosis in the bladder: three cases with different appearance. | journal = Scand J Urol | volume = 48 | issue = 5 | pages = 489-92 | month = Oct | year = 2014 | doi = 10.3109/21681805.2014.920414 | PMID = 24857645 }}</ref>
*Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.<ref name=pmid25366012/><ref name=pmid24857645/>
**Systemic [[amyloidosis]] should be excluded.<ref name=pmid24857645>{{Cite journal  | last1 = Schou-Jensen | first1 = KS. | last2 = Dahl | first2 = C. | last3 = Pilt | first3 = AP. | last4 = Azawi | first4 = NH. | title = Amyloidosis in the bladder: three cases with different appearance. | journal = Scand J Urol | volume = 48 | issue = 5 | pages = 489-92 | month = Oct | year = 2014 | doi = 10.3109/21681805.2014.920414 | PMID = 24857645 }}</ref>
*May clinically mimic bladder cancer.<ref name=pmid25366012/>
*May clinically mimic bladder cancer.<ref name=pmid25366012/>



Revision as of 18:19, 2 October 2015

Urinary bladder amyloidosis, more formally primary urinary bladder amyloidosis, is a rare benign condition of urinary bladder that can mimic cancer of the urinary bladder.[1]

General

  • Primary bladder amyloidosis is rare - approximately 200 reported cases as of 2014.[1][2]
  • May clinically mimic bladder cancer.[1]

Gross

  • Urinary bladder wall thickening.[1]

Microscopic

Features:

  • Lamina propria with amyloid (amorphous, paucicellular, pink material on H&E - classically "cracked").

Stains

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Urinary Bladder, Transurethral Resection:
- Urothelial mucosa with amyloidosis and mild chronic inflammation.
- Benign muscularis propria present.
- NEGATIVE for urothelial carcinoma in situ.
- NEGATIVE for malignancy.

Comment: 
Congo red staining and polarization confirm the presence of amyloid.

Systemic causes of amyloidosis should be considered clinically.

See also

References

  1. 1.0 1.1 1.2 1.3 Kobayashi, T.; Roberts, J.; Levine, J.; Degrado, J. (2014). "Primary bladder amyloidosis.". Intern Med 53 (21): 2511-3. PMID 25366012.
  2. 2.0 2.1 Schou-Jensen, KS.; Dahl, C.; Pilt, AP.; Azawi, NH. (Oct 2014). "Amyloidosis in the bladder: three cases with different appearance.". Scand J Urol 48 (5): 489-92. doi:10.3109/21681805.2014.920414. PMID 24857645.