Difference between revisions of "Urachal carcinoma"

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#redirect [[Urinary_bladder#Urachal_carcinoma]]
'''Urachal carcinoma''' is an uncommon [[cancer|malignant tumour]] that arises from the urachus.  Most urachal carcinomas are ''[[adenocarcinoma]]s''.
 
==General==
*Very rare<ref name=pmid16826585>{{Cite journal  | last1 = Ashley | first1 = RA. | last2 = Inman | first2 = BA. | last3 = Sebo | first3 = TJ. | last4 = Leibovich | first4 = BC. | last5 = Blute | first5 = ML. | last6 = Kwon | first6 = ED. | last7 = Zincke | first7 = H. | title = Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy. | journal = Cancer | volume = 107 | issue = 4 | pages = 712-20 | month = Aug | year = 2006 | doi = 10.1002/cncr.22060 | PMID = 16826585 }}</ref>~ 0.2% of bladder cancers.<ref name=pmid22901574>{{Cite journal  | last1 = Bruins | first1 = HM. | last2 = Visser | first2 = O. | last3 = Ploeg | first3 = M. | last4 = Hulsbergen-van de Kaa | first4 = CA. | last5 = Kiemeney | first5 = LA. | last6 = Witjes | first6 = JA. | title = The clinical epidemiology of urachal carcinoma: results of a large, population based study. | journal = J Urol | volume = 188 | issue = 4 | pages = 1102-7 | month = Oct | year = 2012 | doi = 10.1016/j.juro.2012.06.020 | PMID = 22901574 }}</ref>
*Younger <55 years-old.
 
Treatment:
*Partial cystectomy +/- umbilectomy.
 
==Gross==
*Lesion must be in urachus or dome of urinary bladder.
 
==Microscopic==
Features:
*Usually adenocarcinoma.
*Adjacent urothelium typically benign.
 
DDx:<ref name=Ref_Amin2-143>{{Ref Amin|2-143}}</ref>
*[[Adenocarcinoma of the urinary bladder]].
*Invasive [[urothelial carcinoma]] with glandular differentiation.
*Metastatic adenocarcinoma/adenocarcinoma extending from another structure, e.g. [[colorectal adenocarcinoma]].
 
===Patterns===
*Enteric - looks like colonic adenocarcinoma.
*Mucinous.
*Signet ring.
 
Note:
*Urachal carcinoma may be ''nonglandular''.<ref name=pmid22301493>{{Cite journal  | last1 = Paner | first1 = GP. | last2 = Barkan | first2 = GA. | last3 = Mehta | first3 = V. | last4 = Sirintrapun | first4 = SJ. | last5 = Tsuzuki | first5 = T. | last6 = Sebo | first6 = TJ. | last7 = Jimenez | first7 = RE. | title = Urachal carcinomas of the nonglandular type: salient features and considerations in pathologic diagnosis. | journal = Am J Surg Pathol | volume = 36 | issue = 3 | pages = 432-42 | month = Mar | year = 2012 | doi = 10.1097/PAS.0b013e31823fe49c | PMID = 22301493 }}</ref>
===Images===
<gallery>
Image:Urachal_carcinoma_-_very_low_mag.jpg | UC - very low mag. (WC)
Image:Urachal_carcinoma_-_low_mag.jpg | UC - low mag. (WC)
Image:Urachal_carcinoma_-_high_mag.jpg | UC - high mag. (WC)
</gallery>
 
==IHC==
Features:<ref name=pmid19252435>{{Cite journal  | last1 = Gopalan | first1 = A. | last2 = Sharp | first2 = DS. | last3 = Fine | first3 = SW. | last4 = Tickoo | first4 = SK. | last5 = Herr | first5 = HW. | last6 = Reuter | first6 = VE. | last7 = Olgac | first7 = S. | title = Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation. | journal = Am J Surg Pathol | volume = 33 | issue = 5 | pages = 659-68 | month = May | year = 2009 | doi = 10.1097/PAS.0b013e31819aa4ae | PMID = 19252435 }}</ref>
*CK20 +ve.
*CK7 +ve/-ve.
*CK34betaE12 +ve/-ve.
*Beta-catenin -- usu cytoplasmic/membranous +ve.
 
Others:<ref name=pmid21572312>{{Cite journal  | last1 = Paner | first1 = GP. | last2 = McKenney | first2 = JK. | last3 = Barkan | first3 = GA. | last4 = Yao | first4 = JL. | last5 = Frankel | first5 = WL. | last6 = Sebo | first6 = TJ. | last7 = Shen | first7 = SS. | last8 = Jimenez | first8 = RE. | title = Immunohistochemical analysis in a morphologic spectrum of urachal epithelial neoplasms: diagnostic implications and pitfalls. | journal = Am J Surg Pathol | volume = 35 | issue = 6 | pages = 787-98 | month = Jun | year = 2011 | doi = 10.1097/PAS.0b013e3182189c11 | PMID = 21572312 }}</ref>
*p63 -ve (+ve in only 3%).
 
UC versus [[CRC]] -- not absolute but useful:
*CK34betaE12 +ve in UC (-ve in CRC).
*Beta-catenin -ve nuclei in UC (+ve nuclei in CRC).
 
==Sign out==
*The diagnosis is clinicopathologic; one needs imaging.<ref name=Ref_Amin2-143>{{Ref Amin|2-143}}</ref>
 
==See also==
[[Urinary bladder]].
 
==References==
{{Reflist|2}}
 
[[Category:Urinary bladder]]
[[Category:Diagnosis]]

Revision as of 00:17, 6 December 2013

Urachal carcinoma is an uncommon malignant tumour that arises from the urachus. Most urachal carcinomas are adenocarcinomas.

General

  • Very rare[1]~ 0.2% of bladder cancers.[2]
  • Younger <55 years-old.

Treatment:

  • Partial cystectomy +/- umbilectomy.

Gross

  • Lesion must be in urachus or dome of urinary bladder.

Microscopic

Features:

  • Usually adenocarcinoma.
  • Adjacent urothelium typically benign.

DDx:[3]

Patterns

  • Enteric - looks like colonic adenocarcinoma.
  • Mucinous.
  • Signet ring.

Note:

  • Urachal carcinoma may be nonglandular.[4]

Images

  • UC - very low mag. (WC)

  • UC - low mag. (WC)

  • UC - high mag. (WC)

IHC

Features:[5]

  • CK20 +ve.
  • CK7 +ve/-ve.
  • CK34betaE12 +ve/-ve.
  • Beta-catenin -- usu cytoplasmic/membranous +ve.

Others:[6]

  • p63 -ve (+ve in only 3%).

UC versus CRC -- not absolute but useful:

  • CK34betaE12 +ve in UC (-ve in CRC).
  • Beta-catenin -ve nuclei in UC (+ve nuclei in CRC).

Sign out

  • The diagnosis is clinicopathologic; one needs imaging.[3]

See also

Urinary bladder.

References

  1. ↑ Ashley, RA.; Inman, BA.; Sebo, TJ.; Leibovich, BC.; Blute, ML.; Kwon, ED.; Zincke, H. (Aug 2006). "Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy.". Cancer 107 (4): 712-20. doi:10.1002/cncr.22060. PMID 16826585.
  2. ↑ Bruins, HM.; Visser, O.; Ploeg, M.; Hulsbergen-van de Kaa, CA.; Kiemeney, LA.; Witjes, JA. (Oct 2012). "The clinical epidemiology of urachal carcinoma: results of a large, population based study.". J Urol 188 (4): 1102-7. doi:10.1016/j.juro.2012.06.020. PMID 22901574.
  3. ↑ 3.0 3.1 Amin, Mahul B. (2010). Diagnostic Pathology: Genitourinary (1st ed.). Amirsys. pp. 2-143. ISBN 978-1931884280.
  4. ↑ Paner, GP.; Barkan, GA.; Mehta, V.; Sirintrapun, SJ.; Tsuzuki, T.; Sebo, TJ.; Jimenez, RE. (Mar 2012). "Urachal carcinomas of the nonglandular type: salient features and considerations in pathologic diagnosis.". Am J Surg Pathol 36 (3): 432-42. doi:10.1097/PAS.0b013e31823fe49c. PMID 22301493.
  5. ↑ Gopalan, A.; Sharp, DS.; Fine, SW.; Tickoo, SK.; Herr, HW.; Reuter, VE.; Olgac, S. (May 2009). "Urachal carcinoma: a clinicopathologic analysis of 24 cases with outcome correlation.". Am J Surg Pathol 33 (5): 659-68. doi:10.1097/PAS.0b013e31819aa4ae. PMID 19252435.
  6. ↑ Paner, GP.; McKenney, JK.; Barkan, GA.; Yao, JL.; Frankel, WL.; Sebo, TJ.; Shen, SS.; Jimenez, RE. (Jun 2011). "Immunohistochemical analysis in a morphologic spectrum of urachal epithelial neoplasms: diagnostic implications and pitfalls.". Am J Surg Pathol 35 (6): 787-98. doi:10.1097/PAS.0b013e3182189c11. PMID 21572312.
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