Tumour regression
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Tumour regression can occur (1) sporadically, or (2) as a consequence of treatment (treatment response).
Sporadic tumour regression
Well-known:
May occur in:
Note:
Microscopic
Features:
- +/-Fibrosis.
- +/-Mucin.
- +/-Inflammation.
- +/-Histiocytes.
Note:
- There are specific criteria for malignant melanoma.
Grading of tumour regression
Colorectal carcinoma
Main article: Colorectal carcinoma
There is a three tiered regression grading system by Ryan et al. for colorectal cancer.[4]
Ovarian carcinoma
Main article: Ovarian carcinoma
This has been examined by McCluggage et al.[5]
References
- ↑ Balzer, BL.; Ulbright, TM. (Jul 2006). "Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases.". Am J Surg Pathol 30 (7): 858-65. doi:10.1097/01.pas.0000209831.24230.56. PMID 16819328.
- ↑ 2.0 2.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 476. ISBN 978-0443066542.
- ↑ Speeckaert, R.; van Geel, N.; Vermaelen, KV.; Lambert, J.; Van Gele, M.; Speeckaert, MM.; Brochez, L. (Apr 2011). "Immune reactions in benign and malignant melanocytic lesions: lessons for immunotherapy.". Pigment Cell Melanoma Res 24 (2): 334-44. doi:10.1111/j.1755-148X.2010.00799.x. PMID 21029398.
- ↑ Ryan, R.; Gibbons, D.; Hyland, JM.; Treanor, D.; White, A.; Mulcahy, HE.; O'Donoghue, DP.; Moriarty, M. et al. (Aug 2005). "Pathological response following long-course neoadjuvant chemoradiotherapy for locally advanced rectal cancer.". Histopathology 47 (2): 141-6. doi:10.1111/j.1365-2559.2005.02176.x. PMID 16045774.
- ↑ McCluggage, WG.; Lyness, RW.; Atkinson, RJ.; Dobbs, SP.; Harley, I.; McClelland, HR.; Price, JH. (Jan 2002). "Morphological effects of chemotherapy on ovarian carcinoma.". J Clin Pathol 55 (1): 27-31. PMID 11825920.