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Difference between revisions of "Tubulocystic carcinoma of the kidney"
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Tubulocystic carcinoma of the kidney (view source)
Revision as of 18:14, 28 February 2017
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| Caption = Tubulocystic renal cell carcinoma. [[H&E stain]]. | | Caption = Tubulocystic renal cell carcinoma. [[H&E stain]]. | ||
| Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma | | Synonyms = low-grade collecting duct carcinoma, tubulocystic renal cell carcinoma | ||
| Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or hobnail morphology, eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | | Micro = cysts of variable size lined by a single layer of epithelium that has a cuboidal, flat, or [[hobnail morphology]], eosinophilic cytoplasm, large nuclei with prominent nucleoli, +/-fibrotic stroma | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]] | | LMDDx = [[papillary renal cell carcinoma]] - especially oncocytic variant, [[renal oncocytoma]], [[cystic nephroma]]/[[mixed epithelial and stromal tumour]], [[multilocular cystic renal cell carcinoma]] | ||
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| Gross = multicystic lesion (bubble wrap-like appearance) | | Gross = multicystic lesion (bubble wrap-like appearance) | ||
| Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | | Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | ||
| Staging = [[kidney cancer staging]] | |||
| Site = [[kidney]] | | Site = [[kidney]] | ||
| Assdx = | | Assdx = | ||
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Features:.<ref name=pmid19011562/> | Features:.<ref name=pmid19011562/> | ||
*Cysts of variable size lined by a single layer of epithelium that has a: | *Cysts of variable size lined by a single layer of epithelium that has a: | ||
**Cuboidal, flat, or hobnail morphology. | **Cuboidal, flat, or [[hobnail morphology]]. | ||
**Eosinophilic cytoplasm. | **Eosinophilic cytoplasm. | ||
**Large nuclei with prominent nucleoli. | **Large nuclei with prominent nucleoli. | ||
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DDx: | DDx: | ||
*[[Papillary renal cell carcinoma]] (oncocytic variant). | *[[Papillary renal cell carcinoma]] (oncocytic variant). | ||
*[[Hereditary leiomyomatosis renal cell carcinoma syndrome associated renal cell carcinoma]]. | |||
*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]]. | *[[Cystic nephroma]]/[[Mixed epithelial and stromal tumour]]. | ||
*[[Multilocular cystic renal | *[[Multilocular cystic renal neoplasm of low malignant potential]] (multilocular cystic renal cell carcinoma). | ||
===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | <gallery> | ||
Image: Tubulocystic renal cell carcinoma -- very low mag.jpg | TC-RCC - very low mag. | Image: Tubulocystic renal cell carcinoma -- very low mag.jpg | TC-RCC - very low mag. | ||
| Line 76: | Line 78: | ||
Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg | TC-RCC - very high mag. | Image: Tubulocystic renal cell carcinoma - alt -- very high mag.jpg | TC-RCC - very high mag. | ||
</gallery> | </gallery> | ||
====Case 2==== | |||
<gallery> | |||
Image: Tubulocystic carcinoma of the kidney -- low mag.jpg | TC - low mag. | |||
Image: Tubulocystic carcinoma of the kidney -- intermed mag.jpg | TC - intermed. mag. | |||
Image: Tubulocystic carcinoma of the kidney -- high mag.jpg | TC - high mag. | |||
Image: Tubulocystic carcinoma of the kidney -- very high mag.jpg | TC - very high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | *[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f14.html#figure-title TCCK - low mag. (nature.com)].<ref name=pmid19494850>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue = | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 }}</ref> | ||
*[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)]. | *[http://www.nature.com/modpathol/journal/v22/n2s/fig_tab/modpathol200970f15.html#figure-title TCCK - intermed. mag. (nature.com)]. | ||
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*RCC +ve. | *RCC +ve. | ||
*Vimentin +ve. | *Vimentin +ve. | ||
*AMACR +ve. | *[[AMACR]] +ve. | ||
*CK7 -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi = | PMID = 23157747 }}</ref>). | *[[CK7]] -ve/+ve (focally in 2/3 tumours<ref name=pmid23157747>{{Cite journal | last1 = Zhang | first1 = SH. | last2 = Shi | first2 = SF. | last3 = Huang | first3 = SF. | last4 = Zhang | first4 = YN. | last5 = Zheng | first5 = YY. | last6 = Chen | first6 = GY. | title = [Clinical and pathologic features of tubulocystic carcinoma of kidney]. | journal = Zhonghua Bing Li Xue Za Zhi | volume = 41 | issue = 8 | pages = 543-6 | month = Aug | year = 2012 | doi = | PMID = 23157747 }}</ref>). | ||
Notes: | Notes: | ||