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Difference between revisions of "Tuberous sclerosis-associated renal cell carcinoma"
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Tuberous sclerosis-associated renal cell carcinoma (view source)
Revision as of 04:17, 20 March 2024
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[[Image:Renal cell carcinoma in TSC - alt -- high mag.jpg|thumb|right|[[Micrograph]] showing renal cell carcinoma in the context of tuberous sclerosis complex. [[H&E stain]]. (WC/Nephron)]] | |||
'''Tuberous sclerosis-associated renal cell carcinoma''', abbreviated '''TSARCC''', is a [[kidney tumour]] that is associated with the syndrome [[tuberous sclerosis]].<ref name=pmid25093518>{{Cite journal | last1 = Guo | first1 = J. | last2 = Tretiakova | first2 = MS. | last3 = Troxell | first3 = ML. | last4 = Osunkoya | first4 = AO. | last5 = Fadare | first5 = O. | last6 = Sangoi | first6 = AR. | last7 = Shen | first7 = SS. | last8 = Lopez-Beltran | first8 = A. | last9 = Mehra | first9 = R. | title = Tuberous Sclerosis-associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1457-67 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000248 | PMID = 25093518 }}</ref> | '''Tuberous sclerosis-associated renal cell carcinoma''', abbreviated '''TSARCC''', is a [[kidney tumour]] that is associated with the syndrome [[tuberous sclerosis]].<ref name=pmid25093518>{{Cite journal | last1 = Guo | first1 = J. | last2 = Tretiakova | first2 = MS. | last3 = Troxell | first3 = ML. | last4 = Osunkoya | first4 = AO. | last5 = Fadare | first5 = O. | last6 = Sangoi | first6 = AR. | last7 = Shen | first7 = SS. | last8 = Lopez-Beltran | first8 = A. | last9 = Mehra | first9 = R. | title = Tuberous Sclerosis-associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients. | journal = Am J Surg Pathol | volume = 38 | issue = 11 | pages = 1457-67 | month = Nov | year = 2014 | doi = 10.1097/PAS.0000000000000248 | PMID = 25093518 }}</ref> | ||
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Notes: | Notes: | ||
*The ''macrocystic architecture composed of cells with granular eosinophilic cytoplasm'' pattern in individuals without documented [[tuberous sclerosis]] is an evolving entity known as ''[[eosinophilic, solid and cystic renal cell carcinoma]]''.<ref name=pmid26414221>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Hes | first2 = O. | last3 = Bonert | first3 = M. | last4 = Lopez | first4 = JI. | last5 = Bonsib | first5 = SM. | last6 = Nesi | first6 = G. | last7 = Comperat | first7 = E. | last8 = Sibony | first8 = M. | last9 = Berney | first9 = DM. | title = Eosinophilic, Solid, and Cystic Renal Cell Carcinoma: Clinicopathologic Study of 16 Unique, Sporadic Neoplasms Occurring in Women. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Sep | year = 2015 | doi = 10.1097/PAS.0000000000000508 | PMID = 26414221 }}</ref> | |||
*There is also a paper by Yang ''et al.''; it describes three different patterns:<ref name=pmid24832166/> | *There is also a paper by Yang ''et al.''; it describes three different patterns:<ref name=pmid24832166/> | ||
*#TSC-associated [[papillary RCC]]. | *#TSC-associated [[papillary RCC]]. | ||
*#[[Renal cell carcinoma, unclassified]]. | *#[[Renal cell carcinoma, unclassified]]. | ||
*#Hybrid oncocytic/chromophobe tumour (HOCT). | *#[[Renal hybrid oncocytic/chromophobe tumour|Hybrid oncocytic/chromophobe tumour]] (HOCT). | ||
DDx: | DDx: | ||
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*[[Unclassified renal cell carcinoma]]. | *[[Unclassified renal cell carcinoma]]. | ||
===Images=== | |||
<gallery> | |||
Image: Renal cell carcinoma in TSC -- very low mag.jpg | RCC-TSC - very low mag. (WC) | |||
Image: Renal cell carcinoma in TSC -- low mag.jpg | RCC-TSC - low mag. (WC) | |||
Image: Renal cell carcinoma in TSC -- intermed mag.jpg | RCC-TSC - intermed. mag. (WC) | |||
Image: Renal cell carcinoma in TSC -- high mag.jpg | RCC-TSC - high mag. (WC) | |||
Image: Renal cell carcinoma in TSC -- very high mag.jpg | RCC-TSC - very high mag. (WC) | |||
Image: Renal cell carcinoma in TSC - alt -- high mag.jpg | RCC-TSC - high mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b -- very low mag.jpg | RCC-TSC - very low mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b2 -- low mag.jpg | RCC-TSC - low mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b1 -- intermed mag.jpg | RCC-TSC - intermed. mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b2 -- intermed mag.jpg | RCC-TSC - intermed. mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b -- high mag.jpg | RCC-TSC - high mag. (WC) | |||
Image: Renal cell carcinoma in TSC - b -- very high mag.jpg | RCC-TSC - very high mag. (WC) | |||
</gallery> | |||
==See also== | ==See also== | ||
*[[Renal tumours]]. | *[[Renal tumours]]. | ||
*[[Tuberous sclerosis]]. | *[[Tuberous sclerosis]]. | ||
*[[ | *[[ELOC-mutated renal cell carcinoma]]. | ||
*[[Renal neoplasms with TSC/mTOR pathway mutations]]. | |||
==References== | ==References== | ||