Account-creators
1,040
edits
Difference between revisions of "Tuberous sclerosis"
Jump to navigation
Jump to search
graphical scheme added
Jensflorian (talk | contribs) (→Associations: SENs) |
Jensflorian (talk | contribs) (graphical scheme added) |
||
| Line 42: | Line 42: | ||
*The same genes (TSC1, TSC2) are implicated in [[PEComa]]s. | *The same genes (TSC1, TSC2) are implicated in [[PEComa]]s. | ||
*Renal lesions are seen in ~60% of patients.<ref name=pmid17003820/> | *Renal lesions are seen in ~60% of patients.<ref name=pmid17003820/> | ||
[[File:TSC.png|thumb300px]] | |||
*Scheme illustrates types of neuropathologic changes in tuberous sclerosis complex. 1- isolated balloon cells in white matter, TSC-/-; 2- heterotopic cluster with dysplastic neurons TSC-/+; 3- subependymal nodules and 4- subependymal giant cell astrocytoma in ependyma of third ventricle (note that this is not usual localisation for both lesions, which is rather ependyma of lateral ventricles) 5- cortical tuber; 6 - linear migration streak. This scheme is based on DiMario, F Brain abnormalities in Tuberous Sclerosis Complex J Child Neurol, 9, 650-657. 2004.<ref>{{Cite journal | last1 = DiMario | first1 = FJ. | title = Brain abnormalities in tuberous sclerosis complex. | journal = J Child Neurol | volume = 19 | issue = 9 | pages = 650-7 | month = Sep | year = 2004 | doi = 10.1177/08830738040190090401 | PMID = 15563010 }}</ref> | |||
Mnemonic '''SALSA HEART''':<ref>URL: [http://www.usmle-forums.com/usmle-step-1-mnemonics/303-tuberous-sclerosis.html http://www.usmle-forums.com/usmle-step-1-mnemonics/303-tuberous-sclerosis.html]. Accessed on: 20 October 2011.</ref> | Mnemonic '''SALSA HEART''':<ref>URL: [http://www.usmle-forums.com/usmle-step-1-mnemonics/303-tuberous-sclerosis.html http://www.usmle-forums.com/usmle-step-1-mnemonics/303-tuberous-sclerosis.html]. Accessed on: 20 October 2011.</ref> | ||