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'''Transmembrane mucin 1''', commonly abbreviated '''MUC1''', is a commonly used [[immunostain]]. | {{ Infobox stain | ||
| Name = {{PAGENAME}} | |||
| Image = EMA_dots_ependymoma.jpg | |||
| Width = | |||
| Caption = EMA staining in ependymoma. | |||
| Abbrev = MUC1, MUC-1, EMA | |||
| Synonyms = epithelial membrane antigen | |||
| Similar = pankeratin | |||
| Clones = | |||
| Use = | |||
| Subspecial = | |||
| Pattern = | |||
| Positive = most [[adenocarcinoma]]s | |||
| Negative = [[basal cell carcinoma]] | |||
| Other = | |||
}} | |||
'''Transmembrane mucin 1''', commonly abbreviated '''MUC1''' (or '''MUC-1'''), is a commonly used [[immunostain]]. | |||
It is also known '''epithelial membrane antigen''', abbreviated '''EMA'''.<ref>{{OMIM|158340}}</ref> | It is also known '''epithelial membrane antigen''', abbreviated '''EMA'''.<ref>{{OMIM|158340}}</ref> | ||
A ring or dot-like expression pattern is typical for ependymoma. <ref>{{Cite journal | last1 = Hasselblatt | first1 = M. | last2 = Paulus | first2 = W. | title = Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas. | journal = Acta Neuropathol | volume = 106 | issue = 4 | pages = 385-8 | month = Oct | year = 2003 | doi = 10.1007/s00401-003-0752-8 | PMID = 12898159 }}</ref> | A ring or dot-like expression pattern is typical for [[ependymoma]].<ref>{{Cite journal | last1 = Hasselblatt | first1 = M. | last2 = Paulus | first2 = W. | title = Sensitivity and specificity of epithelial membrane antigen staining patterns in ependymomas. | journal = Acta Neuropathol | volume = 106 | issue = 4 | pages = 385-8 | month = Oct | year = 2003 | doi = 10.1007/s00401-003-0752-8 | PMID = 12898159 }}</ref> | ||
===Images=== | |||
<gallery> | <gallery> | ||
File:Miningioma (4) EMA.JPG | EMA staining in a meningioma (WC/KGH) | File:Miningioma (4) EMA.JPG | EMA staining in a [[meningioma]]. (WC/KGH) | ||
File:EMA_dots_ependymoma.jpg | EMA staining in a ependymoma (WC/jensflorian) | File:EMA_dots_ependymoma.jpg | EMA staining in a ependymoma. (WC/jensflorian) | ||
</gallery> | </gallery> | ||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
*[[AE1/AE3]]. | |||
*[[Z622]]. | |||
==References== | ==References== | ||
{{Reflist|1}} | {{Reflist|1}} | ||
==External links== | |||
*[http://www.nordiqc.org/Epitopes/EMA/EMA.htm EMA (nordiqc.org)]. | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||