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Thyroid transcription factor-1 (view source)
Revision as of 20:50, 27 November 2023
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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = Lung_adenocarcinoma_-_TTF-1_-_high_mag.jpg | |||
| Width = | |||
| Caption = TTF-1 staining in [[lung adenocarcinoma]]. (WC) | |||
| Abbrev = | |||
| Synonyms = | |||
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| Pattern = nuclear staining | |||
| Positive = [[adenocarcinoma of the lung]], [[small cell carcinoma of the lung]], thyroid, [[hepatocellular carcinoma]] (cytoplasmic staining) | |||
| Negative = [[squamous cell carcinoma of the lung]] | |||
| Other = | |||
}} | |||
'''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi = | PMID = 10721419 }}</ref> | '''Thyroid transcription factor-1''', abbreviated '''TTF-1''' is a transcription factor seen in lung and thyroid.<ref>{{Cite journal | last1 = Ordóñez | first1 = NG. | title = Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas. | journal = Adv Anat Pathol | volume = 7 | issue = 2 | pages = 123-7 | month = Mar | year = 2000 | doi = | PMID = 10721419 }}</ref> | ||
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==Tumours== | ==Tumours== | ||
*[[Lung adenocarcinoma]].<ref>{{Cite journal | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi = | PMID = 12023581 }}</ref> | ===Positive staining=== | ||
*[[Small cell carcinoma of the lung]]. | *[[Lung adenocarcinoma]].<ref name=pmid12023581>{{Cite journal | last1 = Yatabe | first1 = Y. | last2 = Mitsudomi | first2 = T. | last3 = Takahashi | first3 = T. | title = TTF-1 expression in pulmonary adenocarcinomas. | journal = Am J Surg Pathol | volume = 26 | issue = 6 | pages = 767-73 | month = Jun | year = 2002 | doi = | PMID = 12023581 }}</ref> | ||
**[[Small cell carcinoma of the lung]] ~ 91% positive (157 +ve of 173<ref name=pmid37139017>{{cite journal |authors=Sayeda S, Naqvi A, Begum H, Juergens RA, Finley C, Coschi CH, Cutz JC, Bonert M |title=Prevalence of Thyroid Transcription Factor-1 (TTF-1)-Negative Small Cell Carcinoma and Napsin A Positivity in Small Cell Carcinoma in a Cross-Sectional Study of Lung Core Biopsies |journal=Cureus |volume=15 |issue=4 |pages=e37015 |date=April 2023 |pmid=37139017 |pmc=10151064 |doi=10.7759/cureus.37015 |url=}}</ref>). | |||
**[[Adenocarcinoma of the lung]]. | |||
*Thyroid carcinoma. | |||
*[[Hepatocellular carcinoma]] (cytoplasmic staining, nuclei negative).<ref name=pmid22359993>{{Cite journal | last1 = Mishra | first1 = M. | last2 = Morgan | first2 = V. | last3 = Hamati | first3 = AK. | last4 = Al-Abbadi | first4 = M. | title = Carcinoma of unknown primary: check the liver... thanks to TTF-1. | journal = Tenn Med | volume = 105 | issue = 1 | pages = 35-6, 40 | month = Jan | year = 2012 | doi = | PMID = 22359993 }}</ref> | |||
* Spindle cell oncocytoma / Pituicytoma / Granular cell tumor of the pituitary. <ref name=pmid23887161> {{Cite journal | last1 = Mete | first1 = O. | last2 = Lopes | first2 = MB. | last3 = Asa | first3 = SL. | title = Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 11 | pages = 1694-9 | month = Nov | year = 2013 | doi = 10.1097/PAS.0b013e31829723e7 | PMID = 23887161 }}</ref> | |||
*[[Subependymal giant cell astrocytoma]] <ref name=pmid25669749>{{Cite journal | last1 = Hewer | first1 = E. | last2 = Vajtai | first2 = I. | title = Consistent nuclear expression of thyroid transcription factor 1 in subependymal giant cell astrocytomas suggests lineage-restricted histogenesis. | journal = Clin Neuropathol | volume = 34 | issue = 3 | pages = 128-31 | month = | year = | doi = 10.5414/NP300818 | PMID = 25669749 }}</ref> | |||
===Negative=== | ===Negative staining=== | ||
*[[Squamous cell carcinoma of the lung]]. | *[[Squamous cell carcinoma of the lung]]. | ||
*[[SMARCA4-deficient non-small cell carcinoma of the lung]] - typically ~ 5% of [[lung adenocarcinoma]] is TTF-1 negative. | |||
**These cases are often [[CK7]] positive, [[HepPar-1]] positive.<ref name=pmid28038711>{{Cite journal | last1 = Herpel | first1 = E. | last2 = Rieker | first2 = RJ. | last3 = Dienemann | first3 = H. | last4 = Muley | first4 = T. | last5 = Meister | first5 = M. | last6 = Hartmann | first6 = A. | last7 = Warth | first7 = A. | last8 = Agaimy | first8 = A. | title = SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens. | journal = Ann Diagn Pathol | volume = 26 | issue = | pages = 47-51 | month = Feb | year = 2017 | doi = 10.1016/j.anndiagpath.2016.10.006 | PMID = 28038711 }}</ref> | |||
===Images=== | |||
<gallery> | |||
File:Adenocarcinoma-Acinar type TTF1 (5494540752).jpg | TTF1 in pulmonary adenocarcinoma (WC/Yale Rosen). | |||
File:Pituicytoma TTF1.jpg | TTF1 in a [[Pituicytoma]] (WC/jensflorian). | |||
</gallery> | |||
==See also== | ==See also== | ||