Difference between revisions of "Thrombotic thrombocytopenic purpura"

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#Thrombocytopenia.
#Thrombocytopenia.
#Microangiopathic hemolytic anemia.
#Microangiopathic hemolytic anemia.
#*Usu. with schistocytes (fragmented RBCs).<ref>{{Ref Klatt|65}}</ref>
#Transient neurologic symptoms.
#Transient neurologic symptoms.
#Renal failure.
#Renal failure.
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*'''F'''ever.
*'''F'''ever.
*'''T'''hrombocytopenia.
*'''T'''hrombocytopenia.
*'''Y''' - no one knows "Y" it occurs.  
*'''Y''' - no one knows "Y" it occurs.


==Etiology==
==Etiology==

Revision as of 02:34, 14 November 2010

Thrombotic thrombocytopenic purpura is a type of thrombotic microangiopathy.

Classic pentad

It was classically described as the pentad of:[1]

  1. Fever.
  2. Thrombocytopenia.
  3. Microangiopathic hemolytic anemia.
    • Usu. with schistocytes (fragmented RBCs).[2]
  4. Transient neurologic symptoms.
  5. Renal failure.

Mnemonic

HUS/TTP is a CRAFTY syndrome:[3]

  • CNS symptoms.
  • Renal failure.
  • Anemia - microangiopathic hemolytic anemia.
  • Fever.
  • Thrombocytopenia.
  • Y - no one knows "Y" it occurs.

Etiology

Deficiency of plasma enzyme ADAMTS13 which may be:[1]

  • Inherited.
  • Acquired (autoantibodies).

See also

References

  1. 1.0 1.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 669. ISBN 978-1416031215.
  2. Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 65. ISBN 978-1416002741.
  3. URL: http://www.valuemd.com/mnemonics2.php. Accessed on: 8 November 2010.