Difference between revisions of "Testicular atrophy"

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| Micro      = thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis  
| Micro      = thickening of seminiferous tubule basement membrane, decreased sperm/no sperm present, +/-intertubular fibrosis  
| Subtypes  =
| Subtypes  =
| LMDDx      =
| LMDDx      = [[sertoli cell nodule]], [[testicular scar]], [[germ cell neoplasia in situ]], [[seminoma]] - esp. intertubular
| Stains    =
| Stains    =
| IHC        =
| IHC        =
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*Sertoli cells may have a cytoplasm with eosinophilic granules (lysosomes). This is a nonspecific finding described in several contexts.<ref name=pmid1672120>{{Cite journal  | last1 = Nistal | first1 = M. | last2 = Garcia-Rodeja | first2 = E. | last3 = Paniagua | first3 = R. | title = Granular transformation of Sertoli cells in testicular disorders. | journal = Hum Pathol | volume = 22 | issue = 2 | pages = 131-7 | month = Feb | year = 1991 | doi =  | PMID = 1672120 }}</ref>
*Sertoli cells may have a cytoplasm with eosinophilic granules (lysosomes). This is a nonspecific finding described in several contexts.<ref name=pmid1672120>{{Cite journal  | last1 = Nistal | first1 = M. | last2 = Garcia-Rodeja | first2 = E. | last3 = Paniagua | first3 = R. | title = Granular transformation of Sertoli cells in testicular disorders. | journal = Hum Pathol | volume = 22 | issue = 2 | pages = 131-7 | month = Feb | year = 1991 | doi =  | PMID = 1672120 }}</ref>


Other considerations (DDx):
DDx:
*[[Sertoli cell nodule]].
*[[Sertoli cell nodule]].
*[[Testicular scar]].
*[[Testicular scar]].
*[[Intratubular germ cell neoplasia]].
*[[Germ cell neoplasia in situ]] (intratubular germ cell neoplasia).
*[[Seminoma]].
*[[Seminoma]] - especially where intertubular growth is predominant.<ref name=pmid15316315>{{Cite journal  | last1 = Henley | first1 = JD. | last2 = Young | first2 = RH. | last3 = Wade | first3 = CL. | last4 = Ulbright | first4 = TM. | title = Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. | journal = Am J Surg Pathol | volume = 28 | issue = 9 | pages = 1163-8 | month = Sep | year = 2004 | doi =  | PMID = 15316315 }}</ref>


===Images===
===Images===
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TESTICLE, RIGHT, ORCHIECTOMY:
TESTICLE, RIGHT, ORCHIECTOMY:
- ATROPHIC TESTICLE.
- ATROPHIC TESTICLE.
- NEGATIVE FOR INTRATUBULAR GERM CELL NEOPLASIA.
- NEGATIVE FOR GERM CELL NEOPLASIA IN SITU (INTRATUBULAR GERM CELL NEOPLASIA).
- NEGATIVE FOR MALIGNANCY.
- NEGATIVE FOR MALIGNANCY.
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