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Difference between revisions of "Testicular adrenal rest tumour"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Testicular adrenal rest tumour -- intermed. mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Testicular adrenal rest tumour. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]] | | Micro = nests of eosinophilic cells interspersed with thin bands of fibrous tissue, mild (endocrine) [[nuclear atypia]] | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[Leydig cell tumour]] | | LMDDx = [[Leydig cell tumour]], [[adrenal cortical rest]] | ||
| Stains = | | Stains = | ||
| IHC = melan A +ve | | IHC = melan A +ve | ||
| Line 53: | Line 53: | ||
DDx: | DDx: | ||
*[[Leydig cell tumour]] - history different. | *[[Leydig cell tumour]] - history different. | ||
*[[Adrenal cortical rest]] - not a sizable mass lesion and not bilateral.{{fact}} | *[[Adrenal cortical rest]] - architecture different, not a sizable mass lesion and not bilateral.{{fact}} | ||
===Images=== | ===Images=== | ||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037253/figure/f4-jrcr-8-2-46/ TART (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037253/figure/f4-jrcr-8-2-46/ TART (nih.gov)]. | ||
====Case==== | |||
<gallery> | |||
Image: Testicular adrenal rest tumour -- low mag.jpg | TART - low mag. (WC) | |||
Image: Testicular adrenal rest tumour -- intermed. mag.jpg | Image: Testicular adrenal rest tumour -- high mag.jpg | TART - high mag. (WC) | |||
Image: Testicular adrenal rest tumour - alt -- intermed. mag.jpg | TART - intermed. mag. (WC) | |||
Image: Testicular adrenal rest tumour -- high mag.jpg | TART - high mag. (WC) | |||
Image: Testicular adrenal rest tumour -- very high mag.jpg | TART - very high mag. (WC) | |||
Image: Testicular adrenal rest tumour - alt -- high mag.jpg | TART - high mag. (WC) | |||
Image: Testicular adrenal rest tumour - alt -- very high mag.jpg | TART - very high mag. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*Melan A +ve.<ref name=pmid20951518>{{Cite journal | last1 = Mizukami | first1 = H. | last2 = Hamamatsu | first2 = A. | last3 = Mori | first3 = S. | last4 = Hara | first4 = S. | last5 = Kuroda | first5 = M. | last6 = Nagai | first6 = T. | last7 = Fukunaga | first7 = T. | title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. | journal = Forensic Sci Int | volume = 206 | issue = 1-3 | pages = e71-5 | month = Mar | year = 2011 | doi = 10.1016/j.forsciint.2010.09.017 | PMID = 20951518 }}</ref> | *Melan A +ve.<ref name=pmid20951518>{{Cite journal | last1 = Mizukami | first1 = H. | last2 = Hamamatsu | first2 = A. | last3 = Mori | first3 = S. | last4 = Hara | first4 = S. | last5 = Kuroda | first5 = M. | last6 = Nagai | first6 = T. | last7 = Fukunaga | first7 = T. | title = Autopsy and genetic diagnosis of 21-hydroxylase deficiency with bilateral testicular tumors in a case under no medication for over one year. | journal = Forensic Sci Int | volume = 206 | issue = 1-3 | pages = e71-5 | month = Mar | year = 2011 | doi = 10.1016/j.forsciint.2010.09.017 | PMID = 20951518 }}</ref> | ||
*CD56 +ve.<ref name=pmid23984262>{{Cite journal | last1 = Ali | first1 = HH. | last2 = Samkari | first2 = A. | last3 = Arabi | first3 = H. | title = Testicular adrenal rest "tumor" or Leydig cell tumor? A report of a challenging case with literature review. | journal = Avicenna J Med | volume = 3 | issue = 1 | pages = 15-9 | month = Jan | year = 2013 | doi = 10.4103/2231-0770.112789 | PMID = 23984262 }}</ref> | |||
*AR -ve.<ref name=pmid23984262/> | |||
==Molecular== | ==Molecular== | ||