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Difference between revisions of "Testicular adrenal rest tumour"
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Testicular adrenal rest tumour (view source)
Revision as of 04:11, 15 July 2015
, 04:11, 15 July 2015no edit summary
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*Benign.<ref name=pmid25485724>{{Cite journal | last1 = Smeets | first1 = EE. | last2 = Span | first2 = PN. | last3 = van Herwaarden | first3 = AE. | last4 = Wevers | first4 = RA. | last5 = Hermus | first5 = AR. | last6 = Sweep | first6 = FC. | last7 = Claahsen-van der Grinten | first7 = HL. | title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. | journal = J Clin Endocrinol Metab | volume = 100 | issue = 3 | pages = E524-30 | month = Mar | year = 2015 | doi = 10.1210/jc.2014-2036 | PMID = 25485724 }}</ref> | *Benign.<ref name=pmid25485724>{{Cite journal | last1 = Smeets | first1 = EE. | last2 = Span | first2 = PN. | last3 = van Herwaarden | first3 = AE. | last4 = Wevers | first4 = RA. | last5 = Hermus | first5 = AR. | last6 = Sweep | first6 = FC. | last7 = Claahsen-van der Grinten | first7 = HL. | title = Molecular characterization of testicular adrenal rest tumors in congenital adrenal hyperplasia: lesions with both adrenocortical and Leydig cell features. | journal = J Clin Endocrinol Metab | volume = 100 | issue = 3 | pages = E524-30 | month = Mar | year = 2015 | doi = 10.1210/jc.2014-2036 | PMID = 25485724 }}</ref> | ||
*May overlap with [[Leydig cell tumour]] - see ''molecular'' section. | *May overlap with [[Leydig cell tumour]] - see ''molecular'' section. | ||
*Associated with congenital adrenal hyperplasia. | *Associated with ''congenital adrenal hyperplasia''. | ||
** | **Due to mutation in CYP21A2.<ref name=pmid19531083>{{Cite journal | last1 = Mouritsen | first1 = A. | last2 = Jørgensen | first2 = N. | last3 = Main | first3 = KM. | last4 = Schwartz | first4 = M. | last5 = Juul | first5 = A. | title = Testicular adrenal rest tumours in boys, adolescents and adult men with congenital adrenal hyperplasia may be associated with the CYP21A2 mutation. | journal = Int J Androl | volume = 33 | issue = 3 | pages = 521-7 | month = Jun | year = 2010 | doi = 10.1111/j.1365-2605.2009.00967.x | PMID = 19531083 }}</ref> | ||
**TART prevalence increases with age - one study suggests moderate prevalance at age 10, increasing to 100% of individuals over 16 years of age.<ref>{{Cite journal | last1 = Claahsen-van der Grinten | first1 = HL. | last2 = Dehzad | first2 = F. | last3 = Kamphuis-van Ulzen | first3 = K. | last4 = de Korte | first4 = CL. | title = Increased prevalence of testicular adrenal rest tumours during adolescence in congenital adrenal hyperplasia. | journal = Horm Res Paediatr | volume = 82 | issue = 4 | pages = 238-44 | month = | year = 2014 | doi = 10.1159/000365570 | PMID = 25195868 }}</ref> | |||
Clinical: | Clinical: | ||