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====Comment==== | ====Comment==== | ||
The biopsies show features of chronicity and would be consistent with inflammatory bowel disease (IBD), a drug reaction, and chronic infection. There are no eosinophilic abscesses, as previously noted (see report for specimen S11-3965) and severe inflammation with ulceration. These findings make an eosinophilic enterocolitis unlikely. In the context of an IBD diagnosis, histologic features would favour ulcerative colitis over Crohn's disease. | The biopsies show features of chronicity and would be consistent with inflammatory bowel disease (IBD), a drug reaction, and chronic infection. There are no eosinophilic abscesses, as previously noted (see report for specimen S11-3965) and severe inflammation with ulceration. These findings make an eosinophilic enterocolitis unlikely. In the context of an IBD diagnosis, histologic features would favour ulcerative colitis over Crohn's disease. | ||
== Lymphocytic colitis == | |||
===Final diagnosis=== | |||
Rectosigmoid, biopsy: | |||
- Consistent with lymphocytic colitis, see comment. | |||
===Comment=== | |||
The biopsy shows abundant intraepithelial lymphocytes with a preserved crypt architecture. No thick subepithelial band of collagen is present. No granulomas are identified. The main histomorphologic differential diagnoses include resolving infection and early inflammatory bowel disease. | |||
== Isolated crypt abscess == | |||
<pre> | |||
COLON, BIOPSY: | |||
- ONE ISOLATED CRYPT ABSCESS, ON THE BACKGROUND OF COLONIC MUCOSA WITHOUT SIGNIFICANT | |||
PATHOLOGY, SEE COMMENT. | |||
- NEGATIVE FOR LYMPHOCYTIC COLITIS AND NEGATIVE FOR COLLAGENOUS COLITIS. | |||
- NEGATIVE FOR DYSPLASIA. | |||
COMMENT: | |||
The significance of the crypt abscess is unknown, as the background colon is not | |||
significantly inflamed. A definite cryptitis elsewhere is not identified. Architectural | |||
changes are not apparent. Clinical correlation is suggested. | |||
</pre> | |||
== Cecum == | |||
<pre> | |||
Polyps, Cecum, Polypectomy: | |||
- Fragments of colorectal-type mucosa with cryptitis and crypt | |||
abscesses, see note. | |||
- NEGATIVE for dysplasia. | |||
Note: | |||
The possibility of an underlying inflammatory process involving the GI tract should be considered. The above findings should be correlated with the clinical findings and overall endoscopic impression. | |||
</pre> |
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