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| IHC = TFEB +ve (nuclear staining), HMB-45 +ve, TFE3 -ve | | IHC = TFEB +ve (nuclear staining), HMB-45 +ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = t(6;11)(p21;q12) | | Molecular = TFEB rearrangement, t(6;11)(p21;q12) and others | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
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| Tx = [[nephrectomy]] | | Tx = [[nephrectomy]] | ||
}} | }} | ||
''' | '''TFEB-rearranged renal cell carcinoma''', also '''TFEB RCC''', is a rare [[renal cell carcinoma]] recognized by the WHO classification.<ref name=pmid36645398>{{cite journal |authors=Alaghehbandan R, Siadat F, Trpkov K |title=What's new in the WHO 2022 classification of kidney tumours? |journal=Pathologica |volume=115 |issue=1 |pages=8–22 |date=February 2022 |pmid=36645398 |pmc=10342217 |doi=10.32074/1591-951X-818 |url=}}</ref><ref name=pmid24877033/> | ||
It was previously known as ''renal tumour with t(6;11) translocation'', also ''t(6;11) renal cell carcinoma''. It was first described in children. | |||
It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | It was added to WHO classification of renal neoplasia in the [[Vancouver classification|2012 Vancouver modification]].<ref name=pmid24025519>{{Cite journal | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | last3 = Eble | first3 = JN. | last4 = Egevad | first4 = L. | last5 = Epstein | first5 = JI. | last6 = Grignon | first6 = D. | last7 = Hes | first7 = O. | last8 = Moch | first8 = H. | last9 = Montironi | first9 = R. | title = The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. | journal = Am J Surg Pathol | volume = 37 | issue = 10 | pages = 1469-89 | month = Oct | year = 2013 | doi = 10.1097/PAS.0b013e318299f2d1 | PMID = 24025519 }}</ref> | ||
This entity should '''not''' be confused with [[ | This entity should '''not''' be confused with [[ELOC-mutated renal cell carcinoma]] (previously known as ''TCEB1-mutated renal cell carcinoma''). | ||
==General== | ==General== | ||
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*[[Clear cell renal cell carcinoma]] with eosinophilic cytoplasm. | *[[Clear cell renal cell carcinoma]] with eosinophilic cytoplasm. | ||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
*[[Biphasic hyalinizing psammomatous renal cell carcinoma]]. | |||
===Images=== | ===Images=== | ||
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*RCC +ve (10 +ve of 14<ref name=pmid24618616/>). | *RCC +ve (10 +ve of 14<ref name=pmid24618616/>). | ||
*CD10 +ve (10 +ve of 14<ref name=pmid24618616/>). | *CD10 +ve (10 +ve of 14<ref name=pmid24618616/>). | ||
*Cathepsin K +ve.{{fact}} | |||
*PD-L1 +ve.<ref name=pmid33208882/> | |||
Note: | Note: | ||
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==Molecular== | ==Molecular== | ||
*t(6;11)(p21;q12) MALAT1<ref>{{OMIM|607924}}</ref>/TFEB.<ref name=Ref_WMSP281>{{Ref WMSP|281}}</ref> | *t(6;11)(p21;q12) MALAT1<ref>{{OMIM|607924}}</ref>/TFEB.<ref name=Ref_WMSP281>{{Ref WMSP|281}}</ref> | ||
Others translocations involving TFEB have been described:<ref name=pmid33208882>{{cite journal |authors=Caliò A, Harada S, Brunelli M, Pedron S, Segala D, Portillo SC, Magi-Galluzzi C, Netto GJ, Mackinnon AC, Martignoni G |title=TFEB rearranged renal cell carcinoma. A clinicopathologic and molecular study of 13 cases. Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1 |journal=Mod Pathol |volume=34 |issue=4 |pages=842–850 |date=April 2021 |pmid=33208882 |doi=10.1038/s41379-020-00713-6 |url=}}</ref> | |||
*ACTB-TFEB. | |||
*NEAT1-TFEB. | |||
==See also== | ==See also== |
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