View source for TDP-43

{{ Infobox immunostain
| Name       = {{PAGENAME}}
| Image      = FTLD TSP43 hippocampus.jpg
| Width      =
| Caption    = TDP-43 staining in FTLD-TDP43. (WC)
| Abbrev     =
| Synonyms   =
| Similar    = 
| Clones     =       
| Use        =
| Subspecial =   
| Pattern    = nuclear staining (physiological)
| Positive   = cytoplasmatic staining (pathological)
| Negative   = 
| Other      =
}}
'''TAR-DNA-binding Protein 43''', abbreviated '''TDP-43''' is a neuropathology immunostain used in neurodegenerative diseases.
*Nuclear staining.

==Inclusion morphology==
*fine / coarse skeins.
*dot-like.
*dense-round inclusions.

==Inclusions found==
*Frontotemporal dementias [[FTLD TDP-43]] <ref>{{Cite journal  | last1 = Neumann | first1 = M. | title = Molecular neuropathology of TDP-43 proteinopathies. | journal = Int J Mol Sci | volume = 10 | issue = 1 | pages = 232-46 | month = Jan | year = 2009 | doi = 10.3390/ijms10010232 | PMID = 19333444 }}</ref>
* [[Alzheimer disease]].<ref>{{Cite journal  | last1 = Wilson | first1 = AC. | last2 = Dugger | first2 = BN. | last3 = Dickson | first3 = DW. | last4 = Wang | first4 = DS. | title = TDP-43 in aging and Alzheimer's disease - a review. | journal = Int J Clin Exp Pathol | volume = 4 | issue = 2 | pages = 147-55 | month = Jan | year = 2011 | doi =  | PMID = 21326809 }}</ref>
*[[Chronic traumatic encephalopathy]] (CTE).<ref>{{Cite journal  | last1 = McKee | first1 = AC. | last2 = Cairns | first2 = NJ. | last3 = Dickson | first3 = DW. | last4 = Folkerth | first4 = RD. | last5 = Keene | first5 = CD. | last6 = Litvan | first6 = I. | last7 = Perl | first7 = DP. | last8 = Stein | first8 = TD. | last9 = Vonsattel | first9 = JP. | title = The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. | journal = Acta Neuropathol | volume = 131 | issue = 1 | pages = 75-86 | month = Jan | year = 2016 | doi = 10.1007/s00401-015-1515-z | PMID = 26667418 }}</ref>
*[[Lewy body disease]] (LBD).<ref>{{Cite journal  | last1 = Ling | first1 = H. | last2 = Kara | first2 = E. | last3 = Bandopadhyay | first3 = R. | last4 = Hardy | first4 = J. | last5 = Holton | first5 = J. | last6 = Xiromerisiou | first6 = G. | last7 = Lees | first7 = A. | last8 = Houlden | first8 = H. | last9 = Revesz | first9 = T. | title = TDP-43 pathology in a patient carrying G2019S LRRK2 mutation and a novel p.Q124E MAPT. | journal = Neurobiol Aging | volume = 34 | issue = 12 | pages = 2889.e5-9 | month = Dec | year = 2013 | doi = 10.1016/j.neurobiolaging.2013.04.011 | PMID = 23664753 }}</ref>
*In 30% of non-demented individuals 65yrs and older.<ref>{{Cite journal  | last1 = Wilson | first1 = AC. | last2 = Dugger | first2 = BN. | last3 = Dickson | first3 = DW. | last4 = Wang | first4 = DS. | title = TDP-43 in aging and Alzheimer's disease - a review. | journal = Int J Clin Exp Pathol | volume = 4 | issue = 2 | pages = 147-55 | month = Jan | year = 2011 | doi =  | PMID = 21326809 }}</ref>
*[[Inclusion body myositis]] (IBM).<ref>{{Cite journal  | last1 = D'Agostino | first1 = C. | last2 = Nogalska | first2 = A. | last3 = Engel | first3 = WK. | last4 = Askanas | first4 = V. | title = In sporadic inclusion body myositis muscle fibres TDP-43-positive inclusions are less frequent and robust than p62 inclusions, and are not associated with paired helical filaments. | journal = Neuropathol Appl Neurobiol | volume = 37 | issue = 3 | pages = 315-20 | month = Apr | year = 2011 | doi = 10.1111/j.1365-2990.2010.01108.x | PMID = 20626631 }}</ref>


===Images===
<gallery>
FTLD TSP43 hippocampus.jpg | Pan-TDP43 immunohistochemisty. Pathological cytoplasmic inclusions.
</gallery>

==See also==
*[[Immunohistochemistry]].

==References==
{{Reflist|1}}

[[Category:Immunohistochemistry]]
[[Category:Neuropathology]]