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Difference between revisions of "Stomach carcinoma"
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| Site = [[stomach]] | | Site = [[stomach]] | ||
| Assdx = | | Assdx = | ||
| Syndromes = [[hereditary diffuse gastric cancer]], [[familial adenomatous polyposis]], [[Lynch syndrome]], [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]] | | Syndromes = [[hereditary diffuse gastric cancer]], [[familial adenomatous polyposis]], [[Lynch syndrome]], [[Peutz-Jeghers syndrome]], [[Li-Fraumeni syndrome]], [[Gastric adenocarcinoma and proximal polyposis of the stomach]] (GAPPS) | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
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**[[Peutz-Jeghers syndrome]]. | **[[Peutz-Jeghers syndrome]]. | ||
**[[Lynch syndrome]]. | **[[Lynch syndrome]]. | ||
**[[Gastric adenocarcinoma and proximal polyposis of the stomach]].<ref name=pmid30584346>{{Cite journal | last1 = Rudloff | first1 = U. | title = Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives. | journal = Clin Exp Gastroenterol | volume = 11 | issue = | pages = 447-459 | month = | year = 2018 | doi = 10.2147/CEG.S163227 | PMID = 30584346 }}</ref> | |||
Note: | Note: | ||
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==IHC== | ==IHC== | ||
*AE1/AE3. | |||
*CK7 +ve. | *CK7 +ve. | ||
*CK20 -ve, occasionally +ve. | *CK20 -ve, occasionally +ve. | ||
*[[CDX2]] +ve.<ref name=pmid12604886>{{Cite journal | last1 = Werling | first1 = RW. | last2 = Yaziji | first2 = H. | last3 = Bacchi | first3 = CE. | last4 = Gown | first4 = AM. | title = CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. | journal = Am J Surg Pathol | volume = 27 | issue = 3 | pages = 303-10 | month = Mar | year = 2003 | doi = | PMID = 12604886 }}</ref> | |||
Others: | Others: | ||
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===Biopsy=== | ===Biopsy=== | ||
====Intestinal type==== | ====Intestinal type==== | ||
<pre> | |||
Stomach, Biopsy: | |||
- INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, moderately differentiated. | |||
- Gastric mucosa with intestinal metaplasia. | |||
Comment: | |||
The tumour stains as follows: | |||
POSITIVE: CK7, CDX2. | |||
NEGATIVE: CD20. | |||
HER2 testing has been ordered and will be reported as an addendum. | |||
</pre> | |||
<pre> | <pre> | ||
STOMACH, BIOPSY: | STOMACH, BIOPSY: | ||
- INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, MODERATELY DIFFERENTIATED. | - INVASIVE ADENOCARCINOMA, INTESTINAL TYPE, MODERATELY DIFFERENTIATED. | ||
- Gastric mucosa with moderate chronic active inflammation and extensive | - Gastric mucosa with moderate chronic active inflammation and extensive | ||
intestinal metaplasia. | |||
- Benign small bowel mucosa with erosions. | - Benign small bowel mucosa with erosions. | ||
</pre> | </pre> | ||