Difference between revisions of "Stomach"

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Stomach (view source)

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→‎Inflammatory fibroid polyp: split out
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==Inflammatory fibroid polyp==
==Inflammatory fibroid polyp==
===General===
{{Main|Inflammtory fibroid polyp}}
*Benign.
*Through-out GI tract.
*Can be thought of as granulation tissue-like.<ref name=Ref_DCHH138/>
===Microscopic===
Features:<ref name=pmid20393746>{{Cite journal  | last1 = Daum | first1 = O. | last2 = Hatlova | first2 = J. | last3 = Mandys | first3 = V. | last4 = Grossmann | first4 = P. | last5 = Mukensnabl | first5 = P. | last6 = Benes | first6 = Z. | last7 = Michal | first7 = M. | title = Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). | journal = Virchows Arch | volume = 456 | issue = 5 | pages = 491-7 | month = May | year = 2010 | doi = 10.1007/s00428-010-0914-8 | PMID = 20393746 }}</ref>
*Proliferating spindle cells (fibroid) - '''key feature'''.
**Loosely arranged, concentrically, around blood vessels.<ref name=Ref_GLP115>{{Ref GLP|115}}</ref>
**Perivascular hypocellular zones.<ref name=Ref_DCHH138>{{Ref DCHH|138}}</ref>
*Inflammation:
**Eosinophils - often prominent.
*+/-Leiomyoma/schwannoma-like areas - with nuclear palisading.<ref name=Ref_DCHH138>{{Ref DCHH|138}}</ref>
*+/-Vascular for fibrous tissue.
*Poorly circumscribed/infiltrates into the lamina propria.
 
DDx:
*[[Inflammatory myofibroblastic tumour]].
*[[GIST]] - usually sharply demarcated border.
 
Notes:
*Concentric = share the same centre.<ref>URL: [http://dictionary.reference.com/browse/concentric http://dictionary.reference.com/browse/concentric]. Accessed on: 29 November 2011.</ref>
 
Images:
*[http://commons.wikimedia.org/wiki/File:Inflammatory_fibroid_polyp_-_low_mag.jpg IFP - low mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Inflammatory_fibroid_polyp_-_high_mag.jpg IFP - high mag. (WC)].
 
===IHC===
Features:<ref name=pmid20393746/>
*CD34 +ve.
**There is a CD34 -ve variant.
*Vimentin +ve -- diffuse.<ref>{{Cite journal  | last1 = Kolodziejczyk | first1 = P. | last2 = Yao | first2 = T. | last3 = Tsuneyoshi | first3 = M. | title = Inflammatory fibroid polyp of the stomach. A special reference to an immunohistochemical profile of 42 cases. | journal = Am J Surg Pathol | volume = 17 | issue = 11 | pages = 1159-68 | month = Nov | year = 1993 | doi =  | PMID = 8214261 }}</ref>
 
Others:
*CD117 -ve.<ref name=pmid15163021>{{Cite journal  | last1 = Ozolek | first1 = JA. | last2 = Sasatomi | first2 = E. | last3 = Swalsky | first3 = PA. | last4 = Rao | first4 = U. | last5 = Krasinskas | first5 = A. | last6 = Finkelstein | first6 = SD. | title = Inflammatory fibroid polyps of the gastrointestinal tract: clinical, pathologic, and molecular characteristics. | journal = Appl Immunohistochem Mol Morphol | volume = 12 | issue = 1 | pages = 59-66 | month = Mar | year = 2004 | doi =  | PMID = 15163021 }}
</ref>
*S100 -ve.
 
===Molecular===
*A subset have mutations in PDGFRA.<ref name=pmid20393746>{{Cite journal  | last1 = Daum | first1 = O. | last2 = Hatlova | first2 = J. | last3 = Mandys | first3 = V. | last4 = Grossmann | first4 = P. | last5 = Mukensnabl | first5 = P. | last6 = Benes | first6 = Z. | last7 = Michal | first7 = M. | title = Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek's tumors). | journal = Virchows Arch | volume = 456 | issue = 5 | pages = 491-7 | month = May | year = 2010 | doi = 10.1007/s00428-010-0914-8 | PMID = 20393746 }}</ref>


==Hyperplastic polyp of the stomach==
==Hyperplastic polyp of the stomach==
Michael
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