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Difference between revisions of "Steatohepatitis"
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→Brunt grading system
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===Grading steatohepatitis=== | ===Grading steatohepatitis=== | ||
==== | ====A simple grading system==== | ||
{| class="wikitable sortable" style="text-align: center | {| class="wikitable sortable" style="text-align: center | ||
! Grade | ! Grade | ||
| Line 79: | Line 78: | ||
|- | |- | ||
| 1 | | 1 | ||
| steatosis, [[PMN]]s, occasional ballooning degeneration | | steatosis, [[PMN]]s, occasional ballooning degeneration | ||
|- | |- | ||
| 2 | | 2 | ||
| Line 85: | Line 84: | ||
|- | |- | ||
| 3 | | 3 | ||
| panacinar steatosis | | panacinar steatosis, ballooning obvious | ||
|} | |||
===Brunt grading system=== | |||
Brunt's 1999 paper proposed a system:<ref name=pmid10484010>{{Cite journal | last1 = Brunt | first1 = EM. | last2 = Janney | first2 = CG. | last3 = Di Bisceglie | first3 = AM. | last4 = Neuschwander-Tetri | first4 = BA. | last5 = Bacon | first5 = BR. | title = Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. | journal = Am J Gastroenterol | volume = 94 | issue = 9 | pages = 2467-74 | month = Sep | year = 1999 | doi = 10.1111/j.1572-0241.1999.01377.x | PMID = 10484010 }}</ref> | |||
{| class="wikitable sortable" style="text-align: center | |||
! Grade | |||
! Steatosis | |||
! Neutrophils | |||
! Ballooning | |||
! Chronic inflammation | |||
|- | |||
| 1 | |||
| <=66% | |||
| scattered, rare | |||
| occasional or absent (zone 3) | |||
| none or mild acinar, none or mild portal | |||
|- | |||
| 2 | |||
| any amount (>33%) | |||
| present | |||
| obvious ballooning | |||
| mild or moderate acinar, mild or moderate portal | |||
|- | |||
| 3 | |||
| panacinar, zone 3 predominant | |||
| present | |||
| present, obvious | |||
| mild acinar inflammation, mild or moderate (not marked) portal | |||
|} | |} | ||
====Clinical Research Network system==== | ====Clinical Research Network system==== | ||