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Difference between revisions of "Stains"
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→Verhoeff-van Gieson Stain: copper stains
(→Verhoeff-van Gieson Stain: copper stains) |
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*Collagen = bright red. | *Collagen = bright red. | ||
*Muscle = dull red. | *Muscle = dull red. | ||
==Copper stain== | |||
===General=== | |||
*Used in liver biopsies. | |||
*May be seen in Wilson's disease. | |||
Note: | |||
*Copper staining is a non-specific finding seen in many liver diseases; it is associated with impaired bile secretion.<ref name=pmid2464523>{{cite journal |author=Miyamura H, Nakanuma Y, Kono N |title=Survey of copper granules in liver biopsy specimens from various liver abnormalities other than Wilson's disease and biliary diseases |journal=Gastroenterol. Jpn. |volume=23 |issue=6 |pages=633–8 |year=1988 |month=December |pmid=2464523 |doi= |url=}}</ref> | |||
===Interpretation=== | |||
*Copper = red granules. | |||
Images: | |||
*[http://www.naika.or.jp/im2/42/10/figs/14/fig1.jpg Wilson's disease (naika.or.jp)].<ref>URL: [http://www.naika.or.jp/im2/42/10/14c.aspx http://www.naika.or.jp/im2/42/10/14c.aspx]. Accessed on: 24 January 2011.</ref> | |||
==Shikata stain== | |||
*[[AKA]] Orcein Stain for Copper-Protein, [[AKA]] Shikata-Cu,<ref>[http://www.mayomedicallaboratories.com/test-catalog/Overview/9836 http://www.mayomedicallaboratories.com/test-catalog/Overview/9836]. Accessed on: 24 January 2011.</ref> [[AKA]] Shikata's orcein staining.<ref>URL: [http://informahealthcare.com/doi/abs/10.3109/00313027709085239?journalCode=pat http://informahealthcare.com/doi/abs/10.3109/00313027709085239?journalCode=pat]. Accessed on: 24 January 2011.</ref> | |||
===General=== | |||
*Used in [[medical liver disease|medical liver]] biopsies - used to find copper. | |||
===Interpretation=== | |||
Features:<ref>URL: [http://www.nottingham.ac.uk/pathology/protocols/shikata.html http://www.nottingham.ac.uk/pathology/protocols/shikata.html]. Accessed on: 24 January 2011.</ref> | |||
*Purple/brown = elastin fibres. | |||
*Red = Copper associated protein. | |||
==See also== | ==See also== | ||