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Difference between revisions of "Squamous metaplasia of the rectum/anus"
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Squamous metaplasia of the rectum/anus (view source)
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'''Squamous metaplasia of the anus''' is a metaplastic change of the columnar epithelium. It can histologically mimic [[anal intraepithelial neoplasia]] (AIN), especially. [[high-grade squamous intraepithelial lesion]] (HSIL). | '''Squamous metaplasia of the anus''' is a metaplastic change of the columnar epithelium. It can histologically mimic [[anal intraepithelial neoplasia]] (AIN), especially. [[high-grade squamous intraepithelial lesion]] (HSIL). | ||
==Microscopic== | |||
Features: | |||
* Uniform cell spacing - no crowding - '''key feature'''. | |||
* Nuclei are uniform size and round. | |||
** +/-[[Nucleoli]] present. | |||
*Distinct cell borders | |||
* +/-Intercellular bridges (due to edema) - common. | |||
Negatives: | |||
* No mitoses/rare basal mitoses - think cancer/AIN if you see 'em. | |||
* Usually no hyperchromatism (think cancer/CIN if you see it). | |||
DDx: | |||
*[[Anal intraepithelial lesion]]. | |||
===Images=== | ===Images=== | ||