48,466
edits
m |
|||
(27 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Lung squamous carcinoma -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = Squamous cell carcinoma of the lung. [[ | | Caption = Squamous cell carcinoma of the lung. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = squamous carcinoma of the lung | ||
| Micro = | | Micro = | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[lung adenocarcinoma]], [[non-small cell lung carcinoma]], metastatic [[squamous cell carcinoma]], others | | LMDDx = [[lung adenocarcinoma]], [[non-small cell lung carcinoma]], metastatic [[squamous cell carcinoma]], others | ||
| Stains = | | Stains = | ||
| IHC = p40 +ve, p63 +ve, TTF-1 -ve, CK7 -ve | | IHC = [[p40]] +ve, [[p63]] +ve, [[TTF-1]] -ve, CK7 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Staging = [[lung cancer staging]] | |||
| Site = [[lung]] - see [[lung tumours]] | | Site = [[lung]] - see [[lung tumours]] | ||
| Assdx = | | Assdx = | ||
Line 23: | Line 24: | ||
| Prevalence = common | | Prevalence = common | ||
| Bloodwork = serum calcium elevated | | Bloodwork = serum calcium elevated | ||
| Rads = large airway | | Rads = typically a mass assoc. with a large airway, +/-spiculated, +/-cavitation | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = usually poor | | Prognosis = usually poor | ||
| Other = | | Other = | ||
| ClinDDx = other [[lung tumours]] - esp. [[small cell carcinoma of the lung]] | | ClinDDx = other [[lung tumours]] - esp. [[small cell carcinoma of the lung]] | ||
| Tx = | | Tx = surgical resection if possible | ||
}} | }} | ||
'''Squamous cell carcinoma of the lung''', also '''lung squamous cell carcinoma''', is a common [[cancer|malignant]] [[lung tumour]] that is associated with [[smoking]]. | |||
It is also known as '''squamous carcinoma of the lung''' and '''lung squamous carcinoma'''. | |||
'''Squamous cell carcinoma | '''[[Squamous cell carcinoma]]''' can be abbreviated '''[[SCC]]'''; however, this can be confusing as ''[[small cell carcinoma]]'' is sometimes abbreviated as such. | ||
==General== | ==General== | ||
Line 43: | Line 46: | ||
==Gross== | ==Gross== | ||
* | *Lung mass - usually centrally located, i.e. associated with a large airway. | ||
===Image=== | |||
<gallery> | |||
Image: Ca_bronchus.jpg | Squamous carcinoma of the lung. (WC) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
Line 50: | Line 58: | ||
*Dense appearing cytoplasm, usu. eosinophilic. | *Dense appearing cytoplasm, usu. eosinophilic. | ||
*+/-Small nucleolus. | *+/-Small nucleolus. | ||
*Intracellular bridges - classic. | |||
Note: | |||
*[[Lymphovascular invasion]] (LVI) is relatively common in small tumours. In one series of NSLC tumours less than 2 cm the prevalence of LVI was 16%.<ref>{{cite journal |author=Tao H, Hayashi T, Sano F, ''et al.'' |title=Prognostic impact of lymphovascular invasion compared with that of visceral pleural invasion in patients with pN0 non-small-cell lung cancer and a tumor diameter of 2 cm or smaller |journal=J. Surg. Res. |volume=185 |issue=1 |pages=250–4 |year=2013 |month=November |pmid=23830361 |doi=10.1016/j.jss.2013.05.104 |url=}}</ref> | |||
**Unlike in [[lung adenocarcinoma]], LVI in lung SCC does ''not'' seem to increase the risk of distant metastases and death.<ref name=pmid22617241>{{cite journal |author=Higgins KA, Chino JP, Ready N, ''et al.'' |title=Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy |journal=J Thorac Oncol |volume=7 |issue=7 |pages=1141–7 |year=2012 |month=July |pmid=22617241 |doi=10.1097/JTO.0b013e3182519a42 |url=}}</ref> | |||
DDx: | DDx: | ||
*Metastatic [[squamous cell carcinoma]]. | *Metastatic [[squamous cell carcinoma]]. | ||
*[[Adenocarcinoma of the lung]]. | *[[Adenocarcinoma of the lung]]. | ||
*[[Non-small cell lung carcinoma]] - diagnosis should be | *[[Non-small cell lung carcinoma]] - diagnosis should be avoided if possible. | ||
*[[Small cell carcinoma of the lung]] - for ''basaloid squamous cell carcinoma''. | |||
===Grading=== | |||
There is no consensus on how grading of lung SCC should be done; however, a three tiered system is suggested in the CAP protocol,<ref name=cap_protocol_v3400>URL: [http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-lung-16protocol-3400.pdf]. Version: 3.4.0.0. Accessed on: 23 March 2016.</ref> and some older data is suggestive that such a system for lung SCC can be predictive.<ref name=pmid7092385>{{Cite journal | last1 = Chung | first1 = CK. | last2 = Zaino | first2 = R. | last3 = Stryker | first3 = JA. | last4 = O'Neill | first4 = M. | last5 = DeMuth | first5 = WE. | title = Carcinoma of the lung: evaluation of histological grade and factors influencing prognosis. | journal = Ann Thorac Surg | volume = 33 | issue = 6 | pages = 599-604 | month = Jun | year = 1982 | doi = | PMID = 7092385 }}</ref> | |||
The grading system loosely defined by the CAP protocol (version 3.4.0.0):<ref name=cap_protocol_v3400/> | |||
*Grade 1 (well differentiated) - extensive keratinization. | |||
*Grade 2 (moderately differentiated) - some keratinization. | |||
*Grade 3 (poorly differentiated) - no/little keratinization. | |||
===Images=== | |||
<gallery> | |||
Image: Lung squamous carcinoma -- very low mag.jpg | Lung SCC - very low mag. (WC) | |||
Image: Lung squamous carcinoma -- low mag.jpg | Lung SCC - low mag. (WC) | |||
Image: Lung squamous carcinoma -- intermed mag.jpg | Lung SCC - intermed. mag. (WC) | |||
Image: Lung squamous carcinoma -- high mag.jpg | Lung SCC - high mag. (WC) | |||
Image: Lung squamous carcinoma - alt -- low mag.jpg | Lung SCC - low mag. (WC) | |||
Image: Lung squamous carcinoma - alt -- intermed mag.jpg | Lung SCC - intermed. mag. (WC) | |||
</gallery> | |||
====Cytology==== | |||
<gallery> | |||
Image: Squamous carcinoma lung cytology.gif | Lung SCC - cytology. (WC) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*p40 +ve.<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | *p40 +ve.<ref name=pmid22056955>{{Cite journal | last1 = Bishop | first1 = JA. | last2 = Teruya-Feldstein | first2 = J. | last3 = Westra | first3 = WH. | last4 = Pelosi | first4 = G. | last5 = Travis | first5 = WD. | last6 = Rekhtman | first6 = N. | title = p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. | journal = Mod Pathol | volume = 25 | issue = 3 | pages = 405-15 | month = Mar | year = 2012 | doi = 10.1038/modpathol.2011.173 | PMID = 22056955 }}</ref> | ||
**p63 +ve -- less specific. | **p63 +ve -- less specific. | ||
*Calponin -ve. | |||
*CK5/6 +ve. | |||
Others:<ref name=pmid24126803>{{Cite journal | last1 = Montezuma | first1 = D. | last2 = Azevedo | first2 = R. | last3 = Lopes | first3 = P. | last4 = Vieira | first4 = R. | last5 = Cunha | first5 = AL. | last6 = Henrique | first6 = R. | title = A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. | journal = Virchows Arch | volume = 463 | issue = 6 | pages = 749-54 | month = Dec | year = 2013 | doi = 10.1007/s00428-013-1488-z | PMID = 24126803 }}</ref> | |||
*CK7 -ve. | |||
*CK20 -ve. | |||
*TTF-1 -ve. | *TTF-1 -ve. | ||
**Positive in adenocarcinoma. | **Positive in [[adenocarcinoma of the lung]]. | ||
* | |||
===SCC versus adenocarcinoma=== | |||
*p40 +ve. | |||
*CK5/6 +ve. | *CK5/6 +ve. | ||
*TTF-1 -ve. | |||
*[[Napsin]] -ve. | |||
===Lung SCC versus metastatic bladder urothelial carcinoma=== | |||
As per Gruver ''et al.'':<ref name=pmid23106579>{{Cite journal | last1 = Gruver | first1 = AM. | last2 = Amin | first2 = MB. | last3 = Luthringer | first3 = DJ. | last4 = Westfall | first4 = D. | last5 = Arora | first5 = K. | last6 = Farver | first6 = CF. | last7 = Osunkoya | first7 = AO. | last8 = McKenney | first8 = JK. | last9 = Hansel | first9 = DE. | title = Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. | journal = Arch Pathol Lab Med | volume = 136 | issue = 11 | pages = 1339-46 | month = Nov | year = 2012 | doi = 10.5858/arpa.2011-0575-OA | PMID = 23106579 }}</ref> | |||
{| class="wikitable sortable" | |||
! IHC | |||
! Lung <Br>SCC | |||
! Bladder <br>[[urothelial carcinoma|UCC]] | |||
|- | |||
| CK7 | |||
| 33% +ve | |||
| 100% +ve | |||
|- | |||
| CK20 | |||
| 7% +ve | |||
| 54% +ve | |||
|- | |||
| GATA-3 | |||
| 23% +ve | |||
| 78% +ve | |||
|- | |||
| Desmoglein-3 | |||
| 87% +ve | |||
| 11% +ve | |||
|- | |||
| CK14 | |||
| 77% +ve | |||
| 32% +ve | |||
|- | |||
| Uroplakin III | |||
| 0% +ve | |||
| 14% +ve | |||
|} | |||
==Sign out== | |||
<pre> | |||
Lung, Right Upper Lobe, Core Biopsy: | |||
- SQUAMOUS CELL CARCINOMA. | |||
COMMENT: | |||
The tumour stains as follows: | |||
POSITIVE: p40, CK5/6. | |||
NEGATIVE: TTF-1, napsin. | |||
</pre> | |||
===Block letters=== | |||
<pre> | |||
LUNG, RIGHT UPPER LOBE, BIOPSY: | |||
- INVASIVE SQUAMOUS CELL CARCINOMA. | |||
COMMENT: | |||
The tumour stains as follows: | |||
POSITIVE: p40, CK5/6. | |||
NEGATIVE: TTF-1, napsin. | |||
</pre> | |||
===Resection=== | |||
<pre> | |||
LUNG, RIGHT UPPER LOBE, LOBECTOMY: | |||
- SQUAMOUS CELL CARCINOMA, MODERATELY DIFFERENTIATED, pT2b, pN0. | |||
-- MARGINS NEGATIVE. | |||
-- PLEASE SEE TUMOUR SUMMARY. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Squamous cell carcinoma]]. | *[[Squamous cell carcinoma]]. | ||
*[[Lung tumours]]. | *[[Lung tumours]]. | ||
*[[Lung cytopathology]]. | |||
==References== | ==References== |
edits