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Difference between revisions of "Squamous cell carcinoma of the esophagus"
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Squamous cell carcinoma of the esophagus (view source)
Revision as of 16:54, 28 October 2021
, 16:54, 28 October 2021no edit summary
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Esophageal_squamous_cell_carcinoma_-_a1_--_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Esophageal squamous cell carcinoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = atypical cells | | Micro = atypical squamous cells invading into the lamina propria | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[ | | LMDDx = [[squamous dysplasia of the esophagus]] | ||
| Stains = CK5/6 +ve | | Stains = | ||
| IHC = p63 +'ve, CK5/6 +'ve | |||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 15: | Line 15: | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = | ||
| Site = [[esophagus]] - proximal or mid portion | | Site = [[esophagus]] - usually proximal or mid portion | ||
| Assdx = | | Assdx = [[squamous dysplasia of the esophagus]], [[alcohol]], [[smoking]] | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = dysphagia of solid and liquids | ||
| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
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| Other = | | Other = | ||
| ClinDDx = benign [[esophageal stricture]] | | ClinDDx = benign [[esophageal stricture]] | ||
| Tx = usu. surgery - if feasible | | Tx = usu. surgery - if feasible, chemotherapy, radiation | ||
}} | }} | ||
'''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer. | '''Squamous cell carcinoma of the esophagus''' is a relatively uncommon form of esophageal cancer. | ||
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*Reflux is ''not'' a risk factor for esophageal SCC. | *Reflux is ''not'' a risk factor for esophageal SCC. | ||
**It is a risk factor indirectly for [[esophageal adenocarcinoma]]. | **It is a risk factor indirectly for [[esophageal adenocarcinoma]]. | ||
Clinical: | |||
*Dysphagia of solid and liquids. | |||
*Weight loss. | |||
*Multimodal treatment - surgery, chemotherapy and radiation.<ref name=pmid24480403>{{Cite journal | last1 = Bass | first1 = GA. | last2 = Furlong | first2 = H. | last3 = O'Sullivan | first3 = KE. | last4 = Hennessy | first4 = TP. | last5 = Walsh | first5 = TN. | title = Chemoradiotherapy, with adjuvant surgery for local control, confers a durable survival advantage in adenocarcinoma and squamous cell carcinoma of the oesophagus. | journal = Eur J Cancer | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1016/j.ejca.2013.12.022 | PMID = 24480403 }}</ref> | |||
==Gross== | ==Gross== | ||
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==Microscopic== | ==Microscopic== | ||
Features - atypical squamous cells with | Features - atypical squamous cells with invasion through the basement membrane: | ||
*Cytology: | *Cytology: | ||
**Nucleus - typical central. | **Nucleus - typical central. | ||
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*[[Squamous dysplasia of the esophagus]]. | *[[Squamous dysplasia of the esophagus]]. | ||
*[[Adenocarcinoma of the esophagus]]. | *[[Adenocarcinoma of the esophagus]]. | ||
*[[metastasis|Metastatic]] carcinoma. | |||
===Images=== | ===Images=== | ||