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Difference between revisions of "Squamous cell carcinoma"
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Squamous cell carcinoma (view source)
Revision as of 18:21, 21 September 2020
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{{Main|Squamous cell carcinoma of the head and neck}} | {{Main|Squamous cell carcinoma of the head and neck}} | ||
*Most common tumour of the [[head and neck pathology|head & neck]]. | *Most common tumour of the [[head and neck pathology|head & neck]]. | ||
**[[Tongue squamous cell carcinoma]] is dealt with separately. | |||
*''[[Nasopharyngeal carcinoma]]'' can be considered a variant SCC. | *''[[Nasopharyngeal carcinoma]]'' can be considered a variant SCC. | ||
*HPV-associated SCC is dealt with in ''[[HPV-associated head and neck squamous cell carcinoma]]''. | *HPV-associated SCC is dealt with in ''[[HPV-associated head and neck squamous cell carcinoma]]''. | ||
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==Spindle cell squamous carcinoma== | ==Spindle cell squamous carcinoma== | ||
*[[AKA]] ''sarcomatoid squamous cell carcinoma''.<ref name=pmid18787630 >{{Cite journal | last1 = Hall | first1 = JM. | last2 = Saenger | first2 = JS. | last3 = Fadare | first3 = O. | title = Diagnostic utility of P63 and CD10 in distinguishing cutaneous spindle cell/sarcomatoid squamous cell carcinomas and atypical fibroxanthomas. | journal = Int J Clin Exp Pathol | volume = 1 | issue = 6 | pages = 524-30 | month = Mar | year = 2008 | doi = | PMID = 18787630 }}</ref> | |||
===General=== | ===General=== | ||
*Common spindle cell lesion of the head and neck. | *Common spindle cell lesion of the head and neck. | ||
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=IHC= | =IHC= | ||
Features:<ref name=pmid20823766>{{Cite journal | last1 = Pereira | first1 = TC. | last2 = Share | first2 = SM. | last3 = Magalhães | first3 = AV. | last4 = Silverman | first4 = JF. | title = Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 1 | pages = 10-4 | month = Jan | year = 2011 | doi = 10.1097/PAI.0b013e3181ecaf1c | PMID = 20823766 }}</ref> | Features:<ref name=pmid20823766>{{Cite journal | last1 = Pereira | first1 = TC. | last2 = Share | first2 = SM. | last3 = Magalhães | first3 = AV. | last4 = Silverman | first4 = JF. | title = Can we tell the site of origin of metastatic squamous cell carcinoma? An immunohistochemical tissue microarray study of 194 cases. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 1 | pages = 10-4 | month = Jan | year = 2011 | doi = 10.1097/PAI.0b013e3181ecaf1c | PMID = 20823766 }}</ref> | ||
*CK5/6 +ve. | *[[CK5/6]] +ve. | ||
*p63 +ve. | *[[p63]] +ve. | ||
*K903 +ve. | *K903 +ve. | ||
*p16 +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/> | *[[p16]] +ve/-ve -- dependent on site, +ve favours non-lung SCC.<ref name=pmid20823766/> | ||
*[[p40]] +ve. | |||
Note: | |||
*Immunostains not particularly helpful for establishing primary site of squamous cell carcinoma. p16 may be helpful but is not definitive for non-lung SCC.<ref name=pmid20823766/> | |||
=See also= | =See also= | ||
*[[Adenocarcinoma]]. | *[[Adenocarcinoma]]. | ||
*[[Pseudoepitheliomatous hyperplasia]] - can mimic squamous cell carcinoma. | |||
*[[Basics]]. | *[[Basics]]. | ||