Splenic hamartoma

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Splenic hamartoma, also hamartoma of the spleen, is an uncommon benign lesion of the spleen.

Splenic hamartoma
Diagnosis in short

Splenic hamartoma. H&E stain.

LM variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles
LM DDx littoral cell angioma
IHC factor VIII +ve, CD31 -ve
Gross red, well-circumscribed
Site spleen

Signs +/-splenic enlargement
Symptoms +/-abdominal pain
Prognosis benign
Treatment observe or splenectomy

General

  • Benign.
  • Women > men.[1]
  • May cause pain.[2]

Gross

  • Red lesion.
  • Well-circumscribed.

Image

Microscopic

Features:[3]

  • Variable size irregular vascular channels
  • Red pulp-like disorganized stroma
  • +/-Lymphoid follicles.

DDx:

Images

IHC

Features:

  • CD8 +ve endothelial cells.[3]
  • Factor VIII +ve (diffuse intense).[4]
    • Background spleen -ve.
  • CD31 -ve.[4]
    • Background spleen +ve.

See also

References

  1. Sankar, S.; Thanka, J.; Jagdishchandrabose, S.; Rajendran, S.. "Splenic hamartoma: a rare vascular space occupying lesion of the spleen.". Indian J Pathol Microbiol 54 (1): 223-5. doi:10.4103/0377-4929.77416. PMID 21393931.
  2. Tatekawa, Y.; Kanehiro, H.; Nakajima, Y. (Sep 2007). "Laparoscopic extirpation of splenic hamartoma.". Pediatr Surg Int 23 (9): 911-4. doi:10.1007/s00383-007-1902-1. PMID 17364201.
  3. 3.0 3.1 Lee, H.; Maeda, K. (Jan 2009). "Hamartoma of the spleen.". Arch Pathol Lab Med 133 (1): 147-51. doi:10.1043/1543-2165-133.1.147. PMID 19123729.
  4. 4.0 4.1 Ali, TZ.; Beyer, G.; Taylor, M.; Volpe, C.; Papadimitriou, JC. (Jan 2005). "Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases.". Int J Surg Pathol 13 (1): 103-11. PMID 15735864.