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Difference between revisions of "Splenic hamartoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Splenic_hamartoma_-_very_low_mag.jpg | |||
| Width = | |||
| Caption = Splenic hamartoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = variable size irregular vascular channels, red pulp-like disorganized stroma, +/-lymphoid follicles | |||
| Subtypes = | |||
| LMDDx = [[littoral cell angioma]] | |||
| Stains = | |||
| IHC = factor VIII +ve, CD31 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = red, well-circumscribed | |||
| Grossing = | |||
| Site = [[spleen]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-splenic enlargement | |||
| Symptoms = +/-abdominal pain | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = observe or splenectomy | |||
}} | |||
'''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]]. | '''Splenic hamartoma''', also '''[[hamartoma]] of the spleen''', is an uncommon benign lesion of the [[spleen]]. | ||
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*Benign. | *Benign. | ||
*Women > men.<ref name=pmid21393931>{{Cite journal | last1 = Sankar | first1 = S. | last2 = Thanka | first2 = J. | last3 = Jagdishchandrabose | first3 = S. | last4 = Rajendran | first4 = S. | title = Splenic hamartoma: a rare vascular space occupying lesion of the spleen. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 223-5 | month = | year = | doi = 10.4103/0377-4929.77416 | PMID = 21393931 }}</ref> | *Women > men.<ref name=pmid21393931>{{Cite journal | last1 = Sankar | first1 = S. | last2 = Thanka | first2 = J. | last3 = Jagdishchandrabose | first3 = S. | last4 = Rajendran | first4 = S. | title = Splenic hamartoma: a rare vascular space occupying lesion of the spleen. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 223-5 | month = | year = | doi = 10.4103/0377-4929.77416 | PMID = 21393931 }}</ref> | ||
*May cause pain.<ref>{{Cite journal | last1 = Tatekawa | first1 = Y. | last2 = Kanehiro | first2 = H. | last3 = Nakajima | first3 = Y. | title = Laparoscopic extirpation of splenic hamartoma. | journal = Pediatr Surg Int | volume = 23 | issue = 9 | pages = 911-4 | month = Sep | year = 2007 | doi = 10.1007/s00383-007-1902-1 | PMID = 17364201 }}</ref> | |||
==Gross== | ==Gross== | ||
| Line 13: | Line 45: | ||
Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC) | Image:Spleen_hamartom.jpg | Splenic hamartoma. (WC) | ||
</gallery> | </gallery> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid19123729/> | Features:<ref name=pmid19123729/> | ||
| Line 18: | Line 51: | ||
*Red pulp-like disorganized stroma | *Red pulp-like disorganized stroma | ||
*+/-Lymphoid follicles. | *+/-Lymphoid follicles. | ||
DDx: | |||
*[[Littoral cell angioma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image: | Image: Splenic hamartoma - very low mag.jpg | Splenic hamartoma - very low mag. (WC) | ||
Image: | Image: Splenic hamartoma - low mag.jpg | Splenic hamartoma - low mag. (WC) | ||
Image: | Image: Splenic hamartoma - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | ||
Image: Splenic hamartoma - add - intermed mag.jpg | Splenic hamartoma - intermed. mag. (WC) | |||
Image: Splenic hamartoma - high mag.jpg | Splenic hamartoma - high mag. (WC) | |||
Image: Splenic hamartoma - very high mag.jpg | Splenic hamartoma - very high mag. (WC) | |||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid19123729>{{Cite journal | last1 = Lee | first1 = H. | last2 = Maeda | first2 = K. | title = Hamartoma of the spleen. | journal = Arch Pathol Lab Med | volume = 133 | issue = 1 | pages = 147-51 | month = Jan | year = 2009 | doi = 10.1043/1543-2165-133.1.147 | PMID = 19123729 }} | Features: | ||
</ref> | *CD8 +ve endothelial cells.<ref name=pmid19123729>{{Cite journal | last1 = Lee | first1 = H. | last2 = Maeda | first2 = K. | title = Hamartoma of the spleen. | journal = Arch Pathol Lab Med | volume = 133 | issue = 1 | pages = 147-51 | month = Jan | year = 2009 | doi = 10.1043/1543-2165-133.1.147 | PMID = 19123729 }}</ref> | ||
* | *Factor VIII +ve (diffuse intense).<ref name=pmid15735864>{{Cite journal | last1 = Ali | first1 = TZ. | last2 = Beyer | first2 = G. | last3 = Taylor | first3 = M. | last4 = Volpe | first4 = C. | last5 = Papadimitriou | first5 = JC. | title = Splenic hamartoma: immunohistochemical and ultrastructural profile of two cases. | journal = Int J Surg Pathol | volume = 13 | issue = 1 | pages = 103-11 | month = Jan | year = 2005 | doi = | PMID = 15735864 }}</ref> | ||
**Background spleen -ve. | |||
*CD31 -ve.<ref name=pmid15735864/> | |||
**Background spleen +ve. | |||
==See also== | ==See also== | ||