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Difference between revisions of "Spleen"
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→Splenic enlargement: more
(→Gross pathology: w) |
(→Splenic enlargement: more) |
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=Splenic enlargement= | =Splenic enlargement= | ||
*Portal hypertension (often due to [[cirrhosis]]). | *Portal hypertension (often due to [[cirrhosis]]). | ||
*Lymphoma | *Lymphoma - see below. | ||
*Mononucleosis ([[EBV]] infection). | *Mononucleosis ([[EBV]] infection). | ||
*[[Hemophagocytic syndrome]].<ref name=pmid20127750>{{Cite journal | last1 = Maakaroun | first1 = NR. | last2 = Moanna | first2 = A. | last3 = Jacob | first3 = JT. | last4 = Albrecht | first4 = H. | title = Viral infections associated with haemophagocytic syndrome. | journal = Rev Med Virol | volume = 20 | issue = 2 | pages = 93-105 | month = Mar | year = 2010 | doi = 10.1002/rmv.638 | PMID = 20127750 }} | *[[Hemophagocytic syndrome]].<ref name=pmid20127750>{{Cite journal | last1 = Maakaroun | first1 = NR. | last2 = Moanna | first2 = A. | last3 = Jacob | first3 = JT. | last4 = Albrecht | first4 = H. | title = Viral infections associated with haemophagocytic syndrome. | journal = Rev Med Virol | volume = 20 | issue = 2 | pages = 93-105 | month = Mar | year = 2010 | doi = 10.1002/rmv.638 | PMID = 20127750 }} | ||
</ref> | </ref> | ||
==Lymphoid neoplasms of the spleen== | |||
Most common lymphomas of the spleen:<ref name=pmid22924843>{{Cite journal | last1 = Shimizu-Kohno | first1 = K. | last2 = Kimura | first2 = Y. | last3 = Kiyasu | first3 = J. | last4 = Miyoshi | first4 = H. | last5 = Yoshida | first5 = M. | last6 = Ichikawa | first6 = R. | last7 = Niino | first7 = D. | last8 = Ohshima | first8 = K. | title = Malignant lymphoma of the spleen in Japan: a clinicopathological analysis of 115 cases. | journal = Pathol Int | volume = 62 | issue = 9 | pages = 577-82 | month = Sep | year = 2012 | doi = 10.1111/j.1440-1827.2012.02844.x | PMID = 22924843 }}</ref> | |||
#[[DLBCL]] | |||
#[[Splenic marginal zone lymphoma]] (SMZL).<ref name=pmid20350661>{{Cite journal | last1 = Bennett | first1 = M. | last2 = Schechter | first2 = GP. | title = Treatment of splenic marginal zone lymphoma: splenectomy versus rituximab. | journal = Semin Hematol | volume = 47 | issue = 2 | pages = 143-7 | month = Apr | year = 2010 | doi = 10.1053/j.seminhematol.2010.01.004 | PMID = 20350661 }}</ref> | |||
#[[Follicular lymphoma]] (11 cases), | |||
#Splenic B-cell lymphoma, unclassifiable (SBL-U). | |||
#Peripheral T-cell lymphoma, not otherwise specified. | |||
Less common lymphoid neoplasms of the spleen: | |||
*[[Hairy cell leukemia]]. | |||
*Splenic diffuse red pulp small B cell lymphoma.<ref name=pmid20677173>{{cite journal |author=Baseggio L, Traverse-Glehen A, Callet-Bauchu E, ''et al.'' |title=Relevance of a scoring system including CD11c expression in the identification of splenic diffuse red pulp small B-cell lymphoma (SRPL) |journal=Hematol Oncol |volume=29 |issue=1 |pages=47–51 |year=2011 |month=March |pmid=20677173 |doi=10.1002/hon.957 |url=}}</ref> | |||
==DDx by compartment== | ==DDx by compartment== | ||
===White pulp malignant=== | |||
*[[Diffuse large B-cell lymphoma]]. | |||
*[[Splenic marginal zone lymphoma]]. | |||
*[[Follicular lymphoma]]. | |||
===Red pulp benign=== | ===Red pulp benign=== | ||
*[[Polycythemia rubra vera]] (AKA polycythemia vera). | *[[Polycythemia rubra vera]] (AKA polycythemia vera). | ||