Spindle cell lesions

Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em.

General DDx

Spindle cells should make think:

• Nerve.
• Muscle.
  • Smooth.
  • Skeletal.
• Other.

Malignant fibrous histiocytoma

Work-up (MSH):

• CD34 - GIST, angiosarcoma.
• S100 - neural.
• Desmin - smooth muscle.
• MIB-1 - proliferation.
• CD99 - small blue cell tumours.
• Bcl-2.
• PGP 9.5.
• SMMS - smooth muscle.
• Caldesmon - muscle.
• PDGFR - GIST.
• DOG-1 - GIST (membranous, cytoplasmic), normal pancreas (islets), associated with BRCA1.

See also

• Bone.
• Dermatopathology.
• Hematopathology.
• Soft tissue lesions.
• Immunohistochemistry.