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{{ Infobox immunostain | |||
| Name = {{PAGENAME}} | |||
| Image = Stomach Metastatic Breast Carcinoma, IHC for Estrogen Receptor (5610737866).jpg | |||
| Width = | |||
| Caption = ER+ve in metastatic breast carcinoma. | |||
| Abbrev = ER | |||
| Synonyms = | |||
| Similar = | |||
| Clones = | |||
| Use = | |||
| Subspecial = | |||
| Pattern = nuclear staining | |||
| Positive = Breast and endometrial carcinoma | |||
| Negative = | |||
| Other = | |||
}} | |||
'''Estrogen receptor''', abbreviated '''ER''', is a common [[immunostain]]. | '''Estrogen receptor''', abbreviated '''ER''', is a common [[immunostain]]. | ||
==General== | ==General== | ||
In the context of breast pathology it is a [[Quality#Classification_of_IHC_tests|class II IHC test]], as it is used for treatment decisions by itself.<ref name=pmid20154273>{{Cite journal | last1 = Torlakovic | first1 = EE. | last2 = Riddell | first2 = R. | last3 = Banerjee | first3 = D. | last4 = El-Zimaity | first4 = H. | last5 = Pilavdzic | first5 = D. | last6 = Dawe | first6 = P. | last7 = Magliocco | first7 = A. | last8 = Barnes | first8 = P. | last9 = Berendt | first9 = R. | title = Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. | journal = Am J Clin Pathol | volume = 133 | issue = 3 | pages = 354-65 | month = Mar | year = 2010 | doi = 10.1309/AJCPDYZ1XMF4HJWK | PMID = 20154273 }}</ref> | *Nuclear stain - like most other "p" stains. | ||
*In the context of breast pathology it is a [[Quality#Classification_of_IHC_tests|class II IHC test]], as it is used for treatment decisions by itself.<ref name=pmid20154273>{{Cite journal | last1 = Torlakovic | first1 = EE. | last2 = Riddell | first2 = R. | last3 = Banerjee | first3 = D. | last4 = El-Zimaity | first4 = H. | last5 = Pilavdzic | first5 = D. | last6 = Dawe | first6 = P. | last7 = Magliocco | first7 = A. | last8 = Barnes | first8 = P. | last9 = Berendt | first9 = R. | title = Canadian Association of Pathologists-Association canadienne des pathologistes National Standards Committee/Immunohistochemistry: best practice recommendations for standardization of immunohistochemistry tests. | journal = Am J Clin Pathol | volume = 133 | issue = 3 | pages = 354-65 | month = Mar | year = 2010 | doi = 10.1309/AJCPDYZ1XMF4HJWK | PMID = 20154273 }}</ref> | |||
==Positive== | ==Positive== | ||
*Normal breast - usually patchy staining. | |||
*[[Florid epithelial hyperplasia of the usual type]] - usually patchy staining<ref name=Ref_BP276>{{Ref BP|276}}</ref> - see ''[[Invasive_breast_cancer#Immunostains_for_typing_and_diagnosis|immunostains for typing and diagnosis of breast lesions]]''. | |||
*[[Breast carcinoma]] - most. | *[[Breast carcinoma]] - most. | ||
**[[Ductal carcinoma in situ]] - most. | **[[Ductal carcinoma in situ]] - most, usually diffuse<ref name=Ref_BP276>{{Ref BP|276}}</ref> - see ''[[Invasive_breast_cancer#Immunostains_for_typing_and_diagnosis|immunostains for typing and diagnosis of breast lesions]]''. | ||
**[[Invasive lobular carcinoma]] - all. | **[[Invasive lobular carcinoma]] - all. | ||
**[[Invasive ductal carcinoma of the breast]] - most. | **[[Invasive ductal carcinoma of the breast]] - most. | ||
*[[Endometrial carcinoma]]s. | *[[Endometrial carcinoma]]s. | ||
* PRL-producing [[pituitary adenoma]]s (Prolactioma)<ref>{{Cite journal | last1 = Delgrange | first1 = E. | last2 = Vasiljevic | first2 = A. | last3 = Wierinckx | first3 = A. | last4 = François | first4 = P. | last5 = Jouanneau | first5 = E. | last6 = Raverot | first6 = G. | last7 = Trouillas | first7 = J. | title = Expression of estrogen receptor alpha is associated with prolactin pituitary tumor prognosis and supports the sex-related difference in tumor growth. | journal = Eur J Endocrinol | volume = 172 | issue = 6 | pages = 791-801 | month = Jun | year = 2015 | doi = 10.1530/EJE-14-0990 | PMID = 25792376 }}</ref> | |||
===Occasionally positive=== | ===Occasionally positive=== |