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Difference between revisions of "Soft tissue lesions"
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→Synovial sarcoma: more
(→Tumours of uncertain differentiation: +synovial sar) |
(→Synovial sarcoma: more) |
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===General=== | ===General=== | ||
*Does not arise from cartilage.<ref>WMSP P.627.</ref> | *Does not arise from cartilage.<ref>WMSP P.627.</ref> | ||
*Young adults or adolescents. | |||
*There is some debate whether the translocation is diagnostic. | |||
===Microscopic=== | ===Microscopic=== | ||
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Images: | Images: | ||
*[http://www.scielo.br/img/revistas/ibju/v30n3/3a06f03.jpg Synovial sarcoma (scielo.br)]. | *[http://www.scielo.br/img/revistas/ibju/v30n3/3a06f03.jpg Synovial sarcoma (scielo.br)]. | ||
*[http://www.humpath.com/spip.php?page=article&id_article=1965 Synovial sarcoma - collection of images (humpath.com)]. | |||
===IHC=== | |||
Features:<ref>WMSP P.627.</ref> | |||
*Vimentin +ve + cytokeratin and/or EMA +ve. | |||
*CD99 +ve. | |||
Others: | |||
*Beta-catenin +ve ~70%.<ref name=pmid16740029>{{cite journal |author=Horvai AE, Kramer MJ, O'Donnell R |title=Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=6 |pages=792–8 |year=2006 |month=June |pmid=16740029 |doi= |url=}}</ref> | |||
*Cyclin D1 ~50%.<ref name=pmid16740029/> | |||
===Molecular pathology=== | |||
Unique translocation: | |||
*t(X;18)(p11.2;q11.2).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/300813 http://www.ncbi.nlm.nih.gov/omim/300813]. Accessed on: 30 May 2010.</ref> | |||
=See also= | =See also= | ||