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Difference between revisions of "Soft tissue lesions"
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→Synovial sarcoma: more
m (→IHC: more still) |
(→Synovial sarcoma: more) |
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*Does not arise from cartilage.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | *Does not arise from cartilage.<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
**Usually close to a joint. | **Usually close to a joint. | ||
**Usually distal extremity. | |||
*Young adults or adolescents. | *Young adults or adolescents. | ||
*Poor prognosis. | |||
===Microscopic=== | ===Microscopic=== | ||
| Line 573: | Line 575: | ||
##Spindle cells with features of hemangiopericytoma. | ##Spindle cells with features of hemangiopericytoma. | ||
##Epitheliod glands or nests. | ##Epitheliod glands or nests. | ||
# | #Primitive round cell type. | ||
Features: | |||
*[[Herring bone]] or [[vesicular pattern]] | |||
*Spindle cells. | |||
*+/-Glandular component. | |||
Images: | Images: | ||
| Line 582: | Line 589: | ||
===IHC=== | ===IHC=== | ||
Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
*Vimentin +ve + | *Vimentin +ve. | ||
*EMA +ve. | |||
*BCL2 +ve. | |||
*CD99 +ve. | *CD99 +ve. | ||
| Line 588: | Line 597: | ||
*Beta-catenin +ve ~30-70%.<ref name=pmid16740029>{{cite journal |author=Horvai AE, Kramer MJ, O'Donnell R |title=Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=6 |pages=792–8 |year=2006 |month=June |pmid=16740029 |doi= |url=}}</ref> | *Beta-catenin +ve ~30-70%.<ref name=pmid16740029>{{cite journal |author=Horvai AE, Kramer MJ, O'Donnell R |title=Beta-catenin nuclear expression correlates with cyclin D1 expression in primary and metastatic synovial sarcoma: a tissue microarray study |journal=Arch. Pathol. Lab. Med. |volume=130 |issue=6 |pages=792–8 |year=2006 |month=June |pmid=16740029 |doi= |url=}}</ref> | ||
*Cyclin D1 ~50%.<ref name=pmid16740029/><ref name=pmid15375433>{{cite journal |author=Ng TL, Gown AM, Barry TS, ''et al.'' |title=Nuclear beta-catenin in mesenchymal tumors |journal=Mod. Pathol. |volume=18 |issue=1 |pages=68–74 |year=2005 |month=January |pmid=15375433 |doi=10.1038/modpathol.3800272 |url=}}</ref> | *Cyclin D1 ~50%.<ref name=pmid16740029/><ref name=pmid15375433>{{cite journal |author=Ng TL, Gown AM, Barry TS, ''et al.'' |title=Nuclear beta-catenin in mesenchymal tumors |journal=Mod. Pathol. |volume=18 |issue=1 |pages=68–74 |year=2005 |month=January |pmid=15375433 |doi=10.1038/modpathol.3800272 |url=}}</ref> | ||
*TLE1 +ve nuclear staining; not specific for synovial sarcoma.<ref name=pmid19363472>{{cite journal |author=Kosemehmetoglu K, Vrana JA, Folpe AL |title=TLE1 expression is not specific for synovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms |journal=Mod. Pathol. |volume=22 |issue=7 |pages=872–8 |year=2009 |month=July |pmid=19363472 |doi=10.1038/modpathol.2009.47 |url=http://www.nature.com/modpathol/journal/v22/n7/full/modpathol200947a.html}}</ref><ref>{{cite journal |author=Seo SW, Lee H, Lee HI, Kim HS |title=The role of TLE1 in synovial sarcoma |journal=J Orthop Res |volume= |issue= |pages= |year=2011 |month=February |pmid=21319215 |doi=10.1002/jor.21318 |url=}}</ref> | |||
===Molecular pathology=== | ===Molecular pathology=== | ||
Associated [[translocation]]: | |||
*t(X;18)(p11.2;q11.2).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/300813 http://www.ncbi.nlm.nih.gov/omim/300813]. Accessed on: 30 May 2010.</ref> | *t(X;18)(p11.2;q11.2).<ref>URL: [http://www.ncbi.nlm.nih.gov/omim/300813 http://www.ncbi.nlm.nih.gov/omim/300813]. Accessed on: 30 May 2010.</ref> | ||
**SYT/SSX fusion gene. | |||
Several SSX genes: | |||
*SSX1. | |||
*SSX2 - better survival | |||
*SSX4 - uncommon. | |||
=Other= | =Other= | ||