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Difference between revisions of "Soft tissue lesions"
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=Vascular tumours= | =Vascular tumours= | ||
==Kaposi sarcoma== | |||
===General=== | |||
*Not really a sarcoma. | |||
*Caused by HHV-8. | |||
*Associated with immunodeficiency, e.g. HIV/AIDS. | |||
===Stages=== | |||
It is seen in different stages:<ref>URL: [http://www.histopathology-india.net/KS.htm http://www.histopathology-india.net/KS.htm]. Accessed on: 31 January 2010.</ref> | |||
#Patch stage. | |||
#Plaque stage. | |||
#Nodular stage. | |||
#Lymphangioma-like. (???) | |||
===Microscopic=== | |||
Features:<ref>Klatt. AOP P.23.</ref> | |||
*Vascular channels that anastomose. | |||
*+/-Nuclear atypia. | |||
*Hyaline globules - pale pink globs (that are paler than RBCs) - '''key feature'''. | |||
*+/-Hemosiderin deposits. | |||
DDx: | |||
*Angiosarcoma (have many mitoses). | |||
===IHC=== | |||
*CD31 +ve, CD34 +ve, HHV-8 +ve. | |||
==Angiosarcoma== | |||
*Malignant tumour. | |||
===Microscopic=== | |||
Features: | |||
*Very many small capillaries or irregular shape lined with: | |||
**Atypical nuclei, pleomorphic nuclei. | |||
*Mitoses. | |||
*Cytoplasmic vacuoles. | |||
**Cells trying to form lumina - embryologic. | |||
==Hemangioendothelioma== | ==Hemangioendothelioma== | ||
*Usually benign. | *Usually benign. | ||
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*Nucleolus (???). | *Nucleolus (???). | ||
*+/-Vascular. | *+/-Vascular. | ||
==Rhabdomyosarcoma== | ==Rhabdomyosarcoma== | ||
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*Actin. | *Actin. | ||
=Tumours of uncertain differentiation= | |||
==Clear cell sarcoma== | ==Clear cell sarcoma== | ||
*Known among pathologists as "soft-tissue melanoma" and "melanoma of the soft parts", as it has a strong morphological resemblance.<ref name=pmid18300804>{{cite journal |author=Hisaoka M, Ishida T, Kuo TT, ''et al.'' |title=Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases |journal=Am. J. Surg. Pathol. |volume=32 |issue=3 |pages=452–60 |year=2008 |month=March |pmid=18300804 |doi=10.1097/PAS.0b013e31814b18fb |url=}}</ref> | *Known among pathologists as "soft-tissue melanoma" and "melanoma of the soft parts", as it has a strong morphological resemblance.<ref name=pmid18300804>{{cite journal |author=Hisaoka M, Ishida T, Kuo TT, ''et al.'' |title=Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases |journal=Am. J. Surg. Pathol. |volume=32 |issue=3 |pages=452–60 |year=2008 |month=March |pmid=18300804 |doi=10.1097/PAS.0b013e31814b18fb |url=}}</ref> | ||
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***EWSR1-CREB1 (GI tract associated). | ***EWSR1-CREB1 (GI tract associated). | ||
=See also= | |||
*[[Bone]]. | *[[Bone]]. | ||
*[[Dermatopathology]]. | *[[Dermatopathology]]. | ||
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*[[Spindle cell lesion]]. | *[[Spindle cell lesion]]. | ||
=References= | |||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Weird stuff]] | [[Category:Weird stuff]] | ||