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Difference between revisions of "Soft tissue lesions"
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→Clear cell sarcoma: more
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==Clear cell sarcoma== | ==Clear cell sarcoma== | ||
*Known among pathologists as "soft-tissue melanoma" and "melanoma of the soft parts", as it has a strong morphological resemblance.<ref name=pmid18300804>{{cite journal |author=Hisaoka M, Ishida T, Kuo TT, ''et al.'' |title=Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases |journal=Am. J. Surg. Pathol. |volume=32 |issue=3 |pages=452–60 |year=2008 |month=March |pmid=18300804 |doi=10.1097/PAS.0b013e31814b18fb |url=}}</ref> | *Known among pathologists as "soft-tissue melanoma" and "melanoma of the soft parts", as it has a strong morphological resemblance.<ref name=pmid18300804>{{cite journal |author=Hisaoka M, Ishida T, Kuo TT, ''et al.'' |title=Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases |journal=Am. J. Surg. Pathol. |volume=32 |issue=3 |pages=452–60 |year=2008 |month=March |pmid=18300804 |doi=10.1097/PAS.0b013e31814b18fb |url=}}</ref> | ||
===General=== | |||
*Molecular changes and origin distinct from melanoma. | |||
*Incidence: rare soft tissue tumour. | *Incidence: rare soft tissue tumour. | ||
===Clinical=== | ====Clinical==== | ||
*Usually - deep soft tissue ''or'' extremities. | *Usually - deep soft tissue ''or'' extremities. | ||
*Guarded prognosis. | *Guarded prognosis. | ||
*First described in 1965.<ref>URL: [http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928 http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928]. Accessed on: 5 May 2010.</ref> | *First described in 1965.<ref>URL: [http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928 http://www.informaworld.com/smpp/723576818-750600/ftinterface~db=all~content=a789166263~fulltext=713240928]. Accessed on: 5 May 2010.</ref> | ||
=== | ===Microscopic=== | ||
Features:<ref name=pmid18300804/> | Features:<ref name=pmid18300804/> | ||
*Architecture: sheets or fascicular (bundles) arrangement. | *Architecture: sheets or fascicular (bundles) arrangement. | ||
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===Molecular studies=== | ===Molecular studies=== | ||
*Chromosomal translocation t(12;22)(q13;q12).<ref name=pmid18300804/> | *[[Chromosomal translocation]] t(12;22)(q13;q12).<ref name=pmid18300804/> | ||
**Fusion transcripts: | **Fusion transcripts: | ||
***EWSR1-ATF1. | ***EWSR1-ATF1. | ||