Difference between revisions of "Soft tissue lesions"

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Soft tissue lesions (view source)

Revision as of 02:02, 26 May 2010

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#Intermediate (rarely metastasizing).
#Intermediate (rarely metastasizing).
#Malignant.
#Malignant.
=Other=
==Neurofibromatosis==
Comes in two flavours:
#NF1 (peripheral).
#NF2 (central).
===NF1===
Features (need 2/7 to diagnose):<ref>URL: [http://emedicine.medscape.com/article/1177266-overview http://emedicine.medscape.com/article/1177266-overview]. Accessed on: 3 May 2010.</ref>
*Two or more neurofibromas or one plexiform neurofibroma.
*Café-au-lait spots.
*Freckles in axilla or inguinal area.
*Optic nerve glioma.
*Iris hamartomas (Lisch nodules).
*Sphenoid dysplasia or typical long-bone abnormalities (e.g. bowing).
*First-degree relative with NF1.
===NF2===
Features (need 1/3 to diagnose):<ref>URL: [http://emedicine.medscape.com/article/1178283-overview http://emedicine.medscape.com/article/1178283-overview]. Accessed on: 3 May 2010.</ref>
#Bilateral CNVIII masses on imaging.
#Unilateral CNVIII mass + first-degree relative with NF2.
#First-degree relative with NF2 ''and'' 2/4 of the following:   
## Meningioma.
## Glioma.
## Schwannoma.
## Juvenile cataract.
==Small round blue cell tumours (SRBCT)==
A group of tumours that has a similar histologic appearance.  It is a group of tumours that is seen more often in childhood than adulthood.
===DDx===
*Neuroblastoma.
*Wilm's tumour.
*Alveolar rhabdomyosarcoma.
*Ewing sarcoma/PNET - this entity is dealt with in the ''[[bone]]'' article.
*Lymphoma (diffuse large B cell lymphoma).
*Retinoblastoma.
*Hepatoblastoma.
*Desmoplastic small round cell tumour.
===Microscopic===
Features:
*Sheets of cells, very cellular.
*Small cells ~ 2X RBC diameter.
*Scant cytoplasm.
*Coarse chromatin.
*Nucleolus (???).
*+/-Vascular.


=Adipocytic tumours=
=Adipocytic tumours=
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===IHC===
===IHC===
*Factor VIII +ve.
*Factor VIII +ve.
=Other=
==Neurofibromatosis==
Comes in two flavours:
#NF1 (peripheral).
#NF2 (central).
===NF1===
Features (need 2/7 to diagnose):<ref>URL: [http://emedicine.medscape.com/article/1177266-overview http://emedicine.medscape.com/article/1177266-overview]. Accessed on: 3 May 2010.</ref>
*Two or more neurofibromas or one plexiform neurofibroma.
*Café-au-lait spots.
*Freckles in axilla or inguinal area.
*Optic nerve glioma.
*Iris hamartomas (Lisch nodules).
*Sphenoid dysplasia or typical long-bone abnormalities (e.g. bowing).
*First-degree relative with NF1.
===NF2===
Features (need 1/3 to diagnose):<ref>URL: [http://emedicine.medscape.com/article/1178283-overview http://emedicine.medscape.com/article/1178283-overview]. Accessed on: 3 May 2010.</ref>
#Bilateral CNVIII masses on imaging.
#Unilateral CNVIII mass + first-degree relative with NF2.
#First-degree relative with NF2 ''and'' 2/4 of the following:   
## Meningioma.
## Glioma.
## Schwannoma.
## Juvenile cataract.
==Small round blue cell tumours (SRBCT)==
A group of tumours that has a similar histologic appearance.  It is a group of tumours that is seen more often in childhood than adulthood.
===DDx===
*Neuroblastoma.
*Wilm's tumour.
*Alveolar rhabdomyosarcoma.
*Ewing sarcoma/PNET - this entity is dealt with in the ''[[bone]]'' article.
*Lymphoma (diffuse large B cell lymphoma).
*Retinoblastoma.
*Hepatoblastoma.
*Desmoplastic small round cell tumour.
===Microscopic===
Features:
*Sheets of cells, very cellular.
*Small cells ~ 2X RBC diameter.
*Scant cytoplasm.
*Coarse chromatin.
*Nucleolus (???).
*+/-Vascular.


=Skeletal muscle tumours=
=Skeletal muscle tumours=
Michael
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